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Molecular mechanisms in the actions of morphine and viminol (R2) on rat striatum

, : Molecular mechanisms in the actions of morphine and viminol (R2) on rat striatum. Journal of Pharmacology and Experimental Therapeutics 194(2): 311-318

Analgesic doses of morphine and viminol R2 increase the turnover rate of dopamine (DA) in rat striatum but fail to increase the striatal concentration of adenosine 3',5'-monophosphate (cAMP) or the affinity of tyrosine hydroxylase (TH) for the pteridine cofactor. When morphine is added to striatal homogenates, it changes neither the basal activity of adenylate cyclase nor the enzyme activation by DA. Similarly to morphine, haloperidol enhances the turnover rate of striatal DA, but unlike morphine it increases the affinity of TH for the pteridine cofactor and blocks the in vitro activation of striatal adenylacte cyclase by DA. Morphine (52 mumol/kg i.p.), viminol R2 (7 mumol/kg i.p.) or haloperidol (2.6 mumol/kg i.p.) fails to increase the striatal cAMP contrations. However (+)-amphetamine (4.8 mumol/kg i.p.) increases DA turnover rate and the striatal cAMP content, but, in doses up to 12.8 mumol/kg i.p., it fails to change the affinity of TH for the pteridine cofactor. This study shows that although (+)-amphetamine, haloperidol and morphine increase the turnover rate of striatal DA each drug possesses a specific profile in its action on molecular mechanisms that control the function of striatal dopaminergic synapses.


PMID: 239224

Other references

Vachnadze, N.; Mchedlidze, Q.; Novikova, J.; Suladze, T.; Vachnadze, V., 2016: Screening Of Wild Spread And Cultivated Of Buxus Species Growing In Georgia On The Content Of Alkaloids And Biological Activity. Georgian flora is represented by about 4150 plant species. Many important alkaloid-containing plant species and among of them are species Buxus L. of genus in Adjara. The aims of the research were: sequential screening of the plants for the consis...

Moore, A.H.; Villablanca, J.P.; Cherry, S.E.; Pollack, D.B.; Hovda, D.A., 1998: Quantitative developmental MRI analysis in the vervet monkey does not explain metabolic changes as measured by FDG-PET. Society for Neuroscience Abstracts 24(1-2): 431

Sokolova I.V.; Vasilets L.A., 1991: Effect of the alpha 1 adrenergic receptor agonist phenylephrine on myocardial contractile activity during the induction of acidosis and free radical processes. Biologicheskie Membrany (Moscow) 8(11): 1211-1212

Nachappan, K.M.; Hansen, E.D.; Shanmugasundaram, C.R.; Manoharan, M., 1972: A low cost hydraulic lysimeter for determination of consumptive use requirements of field crops and other studies. [121.3].

Marshall, T.A., 1882: Entomological Society of London, 1872. Part ii. Arranged according to T. A. Marshall's catalogue, published by the Entomological Society of London, 1872. Part ii. Rep. & Tr. Plym. Inst. viii. pp. 137-141. Includes occasional notices of hosts.

Alnaum, H.M.A.; Elhassan, M.M.; Mustafa, F.Y.; Hamid, M.E., 2012: Prevalence of Nocardia species among HIV-positive patients with suspected tuberculosis. The objective of the study was to determine the frequency of nocardiosis in HIV-positive and HIV-negative individuals clinically suspected of having tuberculosis (TB). The study population (n = 171) were those who attended chest hospitals in Khart...

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Kakinoki, K.; Yasuda, A.; Yamaguchi, T., 2005: Comparison of 5% saline and 20% ethanol in LASEK. We performed LASEK refractive surgery on 14 eyes. Epithelial flap was made using 5% saline in 7 eyes and 20% ethanol in 7 eyes. There was no intraoperative complication in either group. During 3 months after surgery, there was no difference betwee...

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Leverkus, M.; Bhol, K.; Hirako, Y.; Pas, H.; Sitaru, C.; Baier, G.; Bröcker, E.B.; Jonkman, M.F.; Ahmed, A.R.; Zillikens, D., 2002: Cicatricial pemphigoid with circulating autoantibodies to beta4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230. Cicatricial pemphigoid is a heterogeneous group of autoimmune subepidermal blistering diseases associated most commonly with autoantibodies to bullous pemphigoid (BP)180 and less frequently with those to laminin 5 or type VII collagen. In addition...