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Neuroendocrine aspects of Parkinson's disease. Therapeutic/effect of a prolactin inhibitor

, : Neuroendocrine aspects of Parkinson's disease. Therapeutic/effect of a prolactin inhibitor. Minerva Medica 67(53): Unknown-Unknown

On the basis of a reassessment of the aetiopathogenetic problem and the neuroendocrine implications, the therapeutic effectiveness of a prolactin inhibitor, 2-alpha-Br-ergocryptine (CB 154), in Parkinson's disease is assessed. Five patients were treated for a total of two weeks using doses between 10 and 15 mg/die. CB 154 was found to act as a dopaminergic receptor agonist at nigro-striatal level, considerably improving tremor and rigidity and to a lesser extent bradykinesia and total disability.


PMID: 1036612

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