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Opioid drug discrimination in humans: stability, specificity and relation to self-reported drug effect


, : Opioid drug discrimination in humans: stability, specificity and relation to self-reported drug effect. Journal of Pharmacology and Experimental Therapeutics 251(3): 1053-1063

Non-dependent volunteers with histories of opioid use were trained in a three-choice drug-discrimination procedure to discriminate the effects of i.m. saline, hydromorphone hydrochloride (3 mg/70 kg) and pentazocine lactate (45 mg/70 kg). In daily sessions, monetary reinforcement was contingent upon correctly identifying by letter code, the drug administered; measures of drug discrimination included an operant procedure and a qualitative and a quantitative choice procedure. Drug effects were assessed concurrently on self reports and physiological indices. After acquisition of the discrimination, subjects were tested for generalization to: 1) a range of doses of the training drugs, 2) p.o. doses of the training drugs and 3) novel drugs. The discrimination was readily learned and all three discrimination measures were comparable. Discrimination performance, as well as self reports and physiological effects, remained stable over the course of the study, suggesting that tolerance did not develop in the daily session procedure. Testing with a range of doses of the training drugs resulted in dose-related effects in discrimination performance, physiological effects and self-reported drug effect. Oral doses of the training drugs resulted in partial generalization to the i.m. training doses, compatible with the attenuated subjective effects of the p.o. doses. Novel drugs (d-amphetamine, 10-20 mg p.o.; Lorazepam, 2-4 mg p.o.; and secobarbital, 100-200 mg p.o.) did not generalize to hydromorphone, but showed partial generalization to both pentazocine and saline. In general, drug-discrimination performance paralleled the patterns of self reports.

US$29.90

PMID: 2481029


Other references

Moore, R.; Walker, D.B., 1981: Studies on vegetative compatibility incompatibility in higher plants 3. involvement of acid phosphatase in the lethal cellular senescence associated with an incompatible hetero graft. To elucidate the events that lead to cellular autolysis, and thus better understand the mechanism of cellular incompatibility between Sedum telephoides and Solanum pennellii stems, the appearance and fate of the hydrolytic enzyme acid phosphatase...

Nyquist, F.; Halvorsen, V.; Madsen, J.E.; Nordsletten, L.; Obrant, K.J., 1999: Ethanol and its effects on fracture healing and bone mass in male rats. Operatively induced, standardized tibia fractures in 42 10-week-old male rats were fixed with intramedullary nails. 21 of the rats were fed liquid containing 15% ethanol. 5 weeks after inducing the fracture, the rats were killed and the total body...

Perilli, L.; Scarfì, G., 1965: On Putti's eburnizing osteosis or Leri's melorheostosis. Considerations on 2 cases: a 39-year follow-up and a recent case. Nuntius Radiologicus 31(7): 740-755

Levitsky, S.; Nerenberg, R.L.; Bombeck, C.T.; Nyhus, L.M., 1974: Are there educational advantages to a surgical clerkship in a university hospital?. Surgery 75(6): 908-914

Xiong, Y.; Yepuri, G.; Montani, J-Pierre.; Ming, X-Fen.; Yang, Z., 2017: Arginase-II Deficiency Extends Lifespan in Mice. The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66<sup>Shc</sup> and to promote cell senescence, apoptosis and inflammation under pathological conditio...

Fursch, H., 1969: Eine neue Scymnus-Art aus Mittelschweden (Col. Cocc). Entomologisk Tidskrift, 90: 55-56

Thilo, E.H.; Townsend, S.F.; Deacon, J., 1993: Infant botulism at 1 week of age: report of two cases. The authors report their experience with two cases of infant botulism in exclusively breastfed neonates in whom symptoms initially appeared at 6 and 8 days of life.

Kwa, S., L.S.; Lebesque, J., V.; Theuws, J., C.M.; Marks, L., B.; Munley, M., T.; Bentel, G.; Oetzel, D.; Spahn, U.; Graham, M., V.; Drzymala, R., E.; Purdy, J., A.; Lichter, A., S.; Martel, M., K.; Ten-Haken, R., K., 1998: Radiation pneumonitis as a function of mean lung dose: An analysis of pooled data of 540 patients. Purpose: To determine the relation between the incidence of radiation pneumonitis and the three-dimensional dose-distribution in the lung. Methods and Materials: In five institutions, the incidence of radiation pneumonitis was evaluated in 540 pat...

Gurel, V.; Sens, M.; Somji, S.; Garrett, S.H.; Sens, D.A., 2003: Expression of the MT-3 protein in the normal breast epithelial cell line MCF-10 is dependant upon the presence of the heavy metal cadmium. Toxicological Sciences 72(S-1): 15, March

Barrado-Solis, N.; Moles-Poveda, P.; Roca-Estelles, M.J.; Quecedo-Estebanez, E.; Gimeno-Carpio, E., 2015: Melanocytic matricoma with melanocytic atypia: report of a new case. Journal of the European Academy of Dermatology and Venereology 30(5): 859-860