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Perinatal upregulation of benzodiazepine receptor ontogenesis: "fearless" and more efficient goal-directed behavior of adult rat progenies


, : Perinatal upregulation of benzodiazepine receptor ontogenesis: "fearless" and more efficient goal-directed behavior of adult rat progenies. Neurotoxicology and Teratology 10(2): 101-111

Pregnant and subsequently lactating rats had ad lib access to drinking water which contained either a benzodiazepine antagonist, Ro 15-1788 or diazepam (DZ). On the average, the rats consumed 2.9 mg/kg/day of Ro 15-1788 or 5.3 mg/kg/day of diazepam over the time period of 3 weeks, from gestation day 14 through postpartum day 14. The control group consumed equivalent volumes of the drug vehicle in water. While Ro 15-1788 had no apparent toxic effects, the numbers of viable pups in the DZ group were significantly reduced. The mean weight of the viable pups, and their gross behavior were not different in all three groups. However, the fully mature 4.5-month-old male progenies exposed to Ro 15-1788 were much more efficient in the radial arm maze test than the control or the diazepam-exposed animals; they rapidly habituated to the novel environment, their exploratory activity was uninhibited by distracting visual and auditory stimuli, they made fewer "working memory" errors in collecting baits, had a much better control over their emotional responses and the autonomic nervous system, as shown by very low defecation/urination scores, and, at the age of 5 months, they had a significant (66%) increase in the density of benzodiazepine receptors in the hippocampal formation, as compared to the control or the diazepam-exposed progenies. In conclusion, the upregulation of benzodiazepine receptor ontogenesis is retained in adult animals and resulted in improved "working memory" and better control over emotional responses that were particularly evident when the animals were challenged by novel and "intimidating" environmental stimuli.

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PMID: 2840561


Other references

Aniskova F.D.; Bol'shakova T.D.; Bunyatyan A.F.; Lukicheva T.I.; Meshcheryakova S.A., 1971: Effect of ultrasound therapy on some indices of neuro humoral regulation in patients with chronic inflammation of the uterine appendages. Akusherstvo i Ginekologiya (Moscow) 47(7): 54-58

Neill J.C.; Cooper S.J., 1989: Evidence for 5 ht 1c receptor mediation of anorexia in the rat. British Journal of Pharmacology 97(SUPPL): 433P

Ciftci, H.; Savas, M.; Gulum, M.; Yeni, E.; Verit, A.; Topal, U., 2011: Evaluation of sexual function in men with orchialgia. This study examined the effect of chronic scrotal pain on sexual function using the International Index of Erectile Function (IIEF). We enrolled 50 patients with symptoms consistent with orchialgia and 50 control subjects without orchialgia, who w...

Macht, D.I.; Spencer, E.C., 1942: Pharmacological interactions of cobra venom and thiamine. Adm. of suitable amts. of vit. B1 to mice makes them more resistant to cobra neurotoxin; excessive doses of thiamine are toxic. Mice maintained on diets deficient in vit. B1 are less resistant to cobra venom. In rats such a deficiency does not aff...

Nydegger, F.; Ammann, H.; Caenegem, L. van; Schick, M., 2000: Self-feeding for dairy cows: an interesting cost effective concept for new and old buildings. Studies were carried out during the winter in Switzerland to compare an outdoor self-feeding system with a feeder mixer wagon. Data are presented on cow behaviour, silage quality, and the design of systems. Investments and annual costs of new and...

Baker, C.L., 1946: The natural history and morphology of Amphiuma. Journal of the Tennessee Academy of Science, 201: 55-91

Debart, F.; Rayner, B.; Degols, G.; Imbach, J.L., 1992: Synthesis and base-pairing properties of the nuclease-resistant alpha-anomeric dodecaribonucleotide alpha-[r(UCUUAACCCACA). The non natural oligoribonucleotide alpha-[r(UCUUAACCCACA)] consisting exclusively of alpha-anomeric ribonucleoside units was synthesized according to the phosphoramidite methodology and the solid support technology. For this purpose, the base-pro...

Nones, Jína.; Nones, J.; Poli, A.; Trentin, A.Gonçalves.; Riella, H.Gracher.; Kuhnen, N.Cabral., 2016: Organophilic treatments of bentonite increase the adsorption of aflatoxin B1 and protect stem cells against cellular damage. Bentonite clays exhibit high adsorptive capacity for contaminants, including aflatoxin B1 (AFB1), a mycotoxin responsible for causing severe toxicity in several species including pigs, poultry and man. Organophilic treatments is known to increase...

Levine L.S.; Lewy J.E.; New M.I., 1974: Hypertension in a new york city high school population prevalence and evaluation. Pediatric Research 8(4): 352

Hayashi, T.; Iwai, K., 1970: Phosphate contents of calf thymus histone fractions. Journal of Biochemistry 68(3): 415-417