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Pharmacokinetic and pharmacodynamic studies of infusions with [Sar 1, Val5, Ala8] angiotensin II (saralasin)


, : Pharmacokinetic and pharmacodynamic studies of infusions with [Sar 1, Val5, Ala8] angiotensin II (saralasin). Klinische Wochenschrift 56 Suppl 1: 97-105

A modification of the infusion test with saralasin, an angiotensin II antagonist for the detection of renin-dependent high blood pressure was studied in renal hypertensive rats and in normotensive and hypertensive subjects. Infusion was started at a rate of 0.01 microgram/kg x min saralasin and the dose was increased ten-fold at 15 min intervals. A significant fall of diastolic blood pressure was observed at the dose of 0.1 microgram/kg x min in renal hypertensive rats, in healthy subjects treated with diuretics, and in patients with renovascular hypertension (saralasin responders). Plasma concentrations of angiotensin I, angiotensin II and of saralasin as well as plasma renin activity were measured. At the lowest infusion rate of 0.01 microgram/kg x min, saralasin plasma levels were 40-fold higher than plasma angiotensin II levels. The decrease in arterial blood pressure occurred at lower doses of saralasin than the increase of plasma renin due to inhibition of feedback on the renin secreting cells. It is concluded that if the saralasin test is performed by a stepwise increase of the infusion rate, potentially dangerous complications such as hypo- or hypertensive reactions can be avoided. The diagnostic reliability is improved by such a procedure since false positive and false negative responses may be prevented. The pressor effect of saralasin in non-renin dependent patients is an advantage since it causes a more marked difference of blood pressure change between saralasin responders and non-responders.

US$29.90

PMID: 732257


Other references

Chen, P.S., 1993: Biotechnology transfer at the National Institutes of Health. Quality Assurance 2(4): 345-352

Kim, S.Won.; Lim, J.Young.; Rhee, C.Kook.; Kim, J.Hye.; Park, C.Kwon.; Kim, T.Jung.; Cho, C.Soo.; Min, C.Ki.; Yoon, H.Kyu., 2016: Effect of roflumilast, novel phosphodiesterase-4 inhibitor, on lung chronic graft-versus-host disease in mice. Chronic graft-versus-host disease (CGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation. Roflumilast has anti-inflammatory effects and has been used in the treatment of inflammatory airway diseases. It is at prese...

Koepcke, W.; Hasford, J.; Weber-Falkensammer, H.; Zwingers, T., 1984: Rheumatology trials: selection of adequate response variables and their evaluation. Response variables in rheumatology trials should describe not only the disease manifestations, but should also measure the changes of impairment, disability and handicap. One should use the following criteria, at least: analogue pain scale, score...

Gaylarde, P.M., 1986: The human skin blanching assay--use and abuse. British Journal of Dermatology 114(5): 636-638

Menke, M.N.; Feke, G.T.; McMeel, J.Wallace.; Branagan, A.; Hunter, Z.; Treon, S.P., 2006: Hyperviscosity-related retinopathy in waldenstrom macroglobulinemia. Objectives: To determine the earliest retinal changes associated with Waldenstrom macroglobulinemia (WM) and to ascertain the serum IgM and serum viscosity (SV) levels at which these changes occur.Methods: Patients with WM were evaluated using in...

Zold, C.L.; Hussain Shuler, M.G., 2015: Theta Oscillations in Visual Cortex Emerge with Experience to Convey Expected Reward Time and Experienced Reward Rate. The primary visual cortex (V1) is widely regarded as faithfully conveying the physical properties of visual stimuli. Thus, experience-induced changes in V1 are often interpreted as improving visual perception (i.e., perceptual learning). Here we d...

Suarez R.K.; Brown G.S.; Hochachka P.W., 1986: Metabolic sources of energy for hummingbird selasphorus rufus flight. It has been known for some two decades that hovering flight in hummingbirds is the most energetically expensive muscle work known among vertebrates, but the metabolic support for such work has never been clarified. Measurement of the maximum activ...

Jia, Y-He.; Dong, X-Shu.; Wang, X-Shan., 2004: Effects of endostatin on expression of vascular endothelial growth factor and its receptors and neovascularization in colonic carcinoma implanted in nude mice. To investigate the antiangiogenic effects of endostatin on colonic carcinoma cell line implanted in nude mice and its mechanism. Nude mice underwent subcutaneous injection with LS-174t colonic carcinoma cell line to generate carcinoma and were ran...

Shumakov V.I.; Levitskii E.R.; Lobanova E.D.; Samusev Y.F., 1977: Hemodynamic condition in the terminal stage of chronic renal insufficiency. Terapevticheskii Arkhiv 49(7): 58-61

Biely, N.D., 1958: Growth of Zander during the first year of life in the Dnieper and closed water basins. Report of the Academy of Sciences Ukraine, 9: 1022-1026