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Pharmacokinetics of sulpiride after oral and intravenous administration in the rat and the dog

, : Pharmacokinetics of sulpiride after oral and intravenous administration in the rat and the dog. Archives Internationales de Pharmacodynamie et de Therapie 223(1): 88-95

The plasma concentration of sulpiride was measured in the rat and in the dog after oral and i.v. administration of the drug. In the rat only traces (less than 1 mug/ml) of sulpiride were detected in plasma after an oral dose of 100 mg/kg. The peak concentrations in 3 dogs given 25, 50 or 100 mg/kg orally were 6.1, 15.6 and 23.9 mug/ml, respectively. The pharmacokinetic data after i.v. injection were compared to earlier observations with the related orthopramide compound, metoclopramide. The half-life of sulpiride in dog plasma (1.6 -- 3.4 hr) is longer than that of metoclopramide, but in the rat there is little difference between the two compounds. Both of the compounds have large total apparent volumes of distribution (1-2 1/kg) in the two species. The marked species difference in the systemic bioavailability of oral sulpiride should be taken into account when the orthopramide drugs are evaluated in pharmacological tests.


PMID: 999405

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