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Pharmacology and clinical applications of cis-platinum

, : Pharmacology and clinical applications of cis-platinum. Urology 25(2): 155-160

Cis-platinum is one of the most efficacious platinum group metals. This agent is widely used in combination with cancer chemotherapy including urologic, gynecologic, esophageal, and head and neck cancers. The initial experience indicated dose-limiting renal nephrotoxicity. However, recent knowledge through animal and clinical experiments have led to finding ways to prevent the undesirable toxicities of this agent even in high doses. The clinical utilization of cisplatinum in various cancers, including testicular, ovarian, bladder, prostate, esophageal, have been encouraging. The use of high-dose cis-platinum (200 mg/m2) has had important therapeutic impact on patients with poor prognostic testicular cancer when compared with the conventional dosage (100 mg/m2). The current use and future potential of this anticancer metal and its potential analogs are reviewed.


PMID: 3881872

Other references

Pennock, L.L., 1947: The dietary management of diabetes. In constructing a diet for diabetics it is considered essential to follow the principles of a normal physiological diet. Simple methods of calculating calorie allowances and diet composition are set out, and typical diets for illustrative cases ar...

Farina, R.; Andreotti, C., 2007: Chronic relapsing allergic contact cheilitis from a toothpaste. A case report. The paper describes the case of a 25 year-old caucasian man whose cheilitis was initially erroneously diagnosed and treated as herpetic cheilitis, and was then correctly identified as a toothpaste allergic contact cheilitis. The remission of the p...

Svirizhev, YuM.; Ovsvyannikov, LL., 1984: On relationship between trophic function and energetic expenditure for food search. Zhurnal Obshchei Biologii, 453: 419-421

Schluger, N.W., 1996: Multi-disciplinary approach to control of tuberculosis. Lancet 347(9013): 1494-1495

Ratcliffe, N.; Newport, R., 2017: The Effect of Visual, Spatial and Temporal Manipulations on Embodiment and Action. The feeling of owning and controlling the body relies on the integration and interpretation of sensory input from multiple sources with respect to existing representations of the bodily self. Illusion paradigms involving multisensory manipulations...

Duong Van Huyen, J-Paul.; Fornes, P.; Guillemain, R.; Amrein, C.; Chevalier, P.; Latremouille, C.; Creput, C.; Glotz, D.; Nochy, D.; Bruneval, P., 2004: Acute vascular humoral rejection in a sensitized cardiac graft recipient: diagnostic value of C4d immunofluorescence. A 37-year-old female patient had a cardiac transplantation for dilated cardiomyopathy. She was sensitized by two pregnancies showing anti-human leukocyte antigen I and II antibodies. The pretransplantation crossmatch was negative, but she develope...

Lambe, L.M., 1914: On new species of Aspideretes from the Belly River Formation of Alberta, with further information regarding the structure of the carapace of Boremys pulchra. Ottawa Proceedings and Transactions of the Royal Society of Canada 3: 8(Sect. iv): 11-16

Lopez Ruiz M.P.; Prieto J.C., 1986: Specific binding of leucine enkephalin to small and large intestinal epithelial cells from guinea pig. 1. Leu-enkephalin receptors were identified in guinea-pig intestinal mucosa in small as well as in large epithelial cells. 2. Binding studies at apparent equilibrium could be interpreted in terms of two populations of receptors in every intestinal...

Magill, G.B.; Killough, J.H., 1953: Oxytetracycline-streptomycin therapy in brucellosis due to Brucella melitensis. A.M.A. Archives of Internal Medicine 91(2): 204-211

Anonymous, 2004: Drugs for breast cancer. Treatment Guidelines From the Medical Letter 3(29): 1-6