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Phase I clinical study of nafazatrom


, : Phase I clinical study of nafazatrom. Investigational New Drugs 4(3): 251-255

Nafazatrom, a synthetic pyrazolinone derivative, has been shown to have substantial antitumor activity in vitro and antitumor and antimetastatic activity in experimental animal systems. The drug has produced no substantial toxicity in preclinical studies and during limited human trials. A phase I clinical trial with this substance was performed at this institution. Nafazatrom was administered orally in a single daily dose. The initial starting dose was 30 mg/m2 and, in the absence of toxicity, subsequent dose levels were reached after 100% escalation. Six patients were treated at each dose level. Forty-eight patients with various metastatic malignant tumors (mostly with melanoma, breast carcinoma, soft tissue sarcoma, renal cell carcinoma and colorectal carcinoma) were entered on this program. No objective remissions were observed. Twelve patients remained stable for periods in excess of 8 weeks. No consistent, substantial or dose-limiting toxicity was detected. The maximum tolerated dose was not reached, and dose escalation was stopped at 4,000 mg/m2/day as initially planned. With the oral preparation, within this dose range and at this schedule, nafazatrom has no antitumor or other biologic activity.

US$29.90

PMID: 3818230


Other references

Garnett, R.M., 1932: Warwings in Norfolk and other counties. British Birds, 25: 223, 269-270, 303, 333

Harwood, M., 1981: Kirtland's warbler - a born loser?. Audubon, 833: 98-111

Dudkowiak, A.; Francke, C.; Amesz, J., 1995: Aggregation of 8,12-diethyl farnesyl bacteriochlorophyll c at low temperature. The effect of temperature on the aggregation of 3(l)R-8,12-diethyl farnesyl bacteriochlorophyll c in a mixture of n-pentane and methylcyclohexane (1/1, v/v) was studied by means of absorption, circular dichroism and fluorescence spectroscopy. At r...

Bobleter O.; Schwald W.; Concin R.; Binder H., 1986: Hydrolysis of cellobiose in dilute sulfuric acid and under hydrothermal conditions. The sulfuric acid hydrolysis rate of cellobiose between pH 2 and 3 is directly proportional to the acid concentration. In good agreement with other authors, anactivation energy of 133 kj/Mol was found under these acidic conditions. The relation of...

Cohen, C., 1937: Some aspects of the reproduction of Stoebe vulgaris, and certain local grass and weeds seeds. The work covered the period 1933-6 and aspects studied included viability, effect of soil water, of carbon dioxide and oxygen, drying seed with and without heat, and effect of chemical treatment on germination, upper temperature limit of germinati...

Naldenow, WT.; Pandurski, IS., 1992: Zwei neue Hohlencyclopiden (Copepoda, Cyclopoida) aus den Grundgewassern Bulgariens. Acanthocyclops balcanicus and Diacyclops chappuisi are described as new species from cavewaters in Bulgaria. A. balcanicus n. sp. belongs to the "kieferi-reductus" group. D. chappuisi n. sp. is most similar to Diacyclops stygius (Chappui...

Morales Ballejo H.M.; Boone J.L.; Eliot R.S., 1991: Influence of diltiazem placebo on the hemodynamic changes caused by stress in mild hypertensives. Clinical Research 39(2): 433A

Warren, M.P.; Jewelewicz, R.; Dyrenfurth, I.; Ans, R.; Khalaf, S.; Vande Wiele, R.L., 1975: The significance of weight loss in the evaluation of pituitary response to LH-RH in women with secondary amenorrhea. Sixteen women with amenorrhea occurring in the setting of severe self-imposed weight loss and 18 women with secondary amenorrhea due to other causes were given LH-RH (luteinizing hormone-releasing hormone). Women with weight loss were found to be...

Jean Mutabaruka; Nathalène Séjourné; Eric Bui; Philippe Birmes; Henri Chabrol, 2012: Traumatic Grief and Traumatic Stress in Survivors 12?Years after the Genocide in Rwanda. The relationship between exposure to traumatic events and traumatic grief and the role of mediating and moderating variables [peritraumatic distress, post traumatic stress disorder (PTSD) symptoms and symptoms of depression] were studied in surviv...

Olson, C.A.; Thomas, J.F., 2017: Telehealth: No Longer an Idea for the Future. Advances in Pediatrics 64(1): 347-370