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Philadelphia-positive ALL with rearrangement of the 1st intron of the BCR gene

, : Philadelphia-positive ALL with rearrangement of the 1st intron of the BCR gene. Sangre 36(6): 505-508

We have studied the haematologic, cytogenetic and molecular features in a patient with Ph positive ALL. The cytogenetic study showed the presence of a Ph chromosome since diagnosis. Molecular analysis showed rearrangement within the first intron of bcr gen instead of M-bcr as in CML. This an evidence of genic fusion between c-abl oncogene and bcr gene and also show the possibility of rearrangement outside M-bcr in these patients.


PMID: 1812584

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