geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Plasma concentration clamping in the rat using a computer-controlled infusion pump


, : Plasma concentration clamping in the rat using a computer-controlled infusion pump. Pharmaceutical Research 9(6): 800-807

We have developed a computer-controlled infusion pump to achieve rapidly and then maintain stable plasma thiopental concentrations in rats. Initially we derived the parameters of a triexponential pharmacokinetic model for thiopental, administered as a brief infusion to 10 rats, using nonlinear regression and standard pharmacokinetic equations. These parameters were incorporated into the pharmacokinetic model of a computer-controlled infusion pump. In a second group of animals this device was used to maintain three consecutive target thiopental concentrations ranging from 5 to 100 micrograms/ml in a stepwise fashion. Arterial blood gases were kept normal through controlled ventilation when necessary. The plasma thiopental concentrations in this second group of animals were generally higher than the target concentrations. The bias in pump performance (median prediction error) was +25%, and the inaccuracy (median absolute prediction error) was 26%. We fit the parameters of a three-compartment model to the plasma thiopental concentrations observed in the second group of animals. This produced a second set of thiopental pharmacokinetic parameters with the unique characteristic of having been derived from a computer controlled infusion study. These parameters were tested prospectively with a computer-controlled infusion pump in a third group of animals. This second set of thiopental pharmacokinetic parameters performed better, with a median prediction error of 0% and a median absolute prediction error of 15%. This study shows that it is possible to achieve rapidly and maintain steady plasma thiopental concentrations in the rat. Our results suggest that it is feasible to derive robust pharmacokinetic parameters from unusual drug dosing approaches, such as employed by a computer-controlled infusion pump.

US$29.90

PMID: 1409364


Other references

Konovalov,N.D.; Konovalov,S.N., 2008: Prospects for the development of sugarbeet production and biologization of agriculture in the Central Chernozem Region. The local programme "Development of agriculture in 2007-2010" envisages an increase in sugarbeet production to 4.2 million t in Tambov province, Russia. This article discusses ways of attaining this target, which can only be met by achie...

Lu, Y.; Jiang, C.; Zhu, Y.; Wang, M.; Bowles, R.J.; Mauffrey, C., 2015: Delayed ORIF of proximal humerus fractures at a minimum of 3 weeks from injury: a functional outcome study. To evaluate the clinical results of open reduction and internal fixation (ORIF) in proximal humerus fractures with delayed presentation. Retrospective comparative study. Level III. From June 2005 to June 2010, thirty-nine (39) proximal humerus fra...

Prakash, S., 1954: Note on natural parasitic infections found in Rattus rattus of Delhi municipal area. The average monthly prevalence of Taenia cysts found in 616 Rattus rattus supplied by the municipal health organization of Dehli during 1950-52 is shown in a table which also includes protozoal infections. The total number of rats containing cysts...

Sakaguchi, E.H.riguchi, M.M.tsumoto, T., 1978: Effect of genistin on the utili. Nippon chikusan gakkai ho 49(9): 653-658

Spence, J.David.; Rayner, B.L., 2016: J Curve and Cuff Artefact, and Diagnostic Inertia in Resistant Hypertension. Hypertension 67(1): 32-33

Han, J.Hao.; Wong, K.Sing., 2008: Is counterpulsation a potential therapy for ischemic stroke?. Despite the rapid progress in stroke prevention, effective acute stroke treatment except for thrombolysis is still lacking. Hypoperfusion is related to unfavorable functional outcome, further strokes and long-term mortality. Therefore, the need fo...

Morgado, Jé.Mário.; Sánchez-Muñoz, L.; Teodósio, C.; Escribano, Lís., 2015: Identification and immunophenotypic characterization of normal and pathological mast cells. Mast cells (MCs) are secretory cells that are central players in human allergic disease and immune responses. With the exception of a few pathological situations, MCs are usually present at relatively low frequencies in most tissues. Since their f...

Brändli, O., 1986: Current status of the chemotherapy of tuberculosis. Schweizerische Rundschau für Medizin Praxis 75(47): 1405-1407

Zhang, W.; Rosenbaum, D.A., 2007: Planning for manual positioning: the end-state comfort effect for manual abduction-adduction. How people take hold of objects depends on what they plan to do with them. Such anticipatory effects reflect motor planning. One class of such anticipatory effects is the end-state comfort effect, a tendency to take hold of an object in an awkward...

Hind, W., 1921: On some carboniferous ammonoids new to English rocks. Proceedings of the Yorkshire Geological Society NS. 1919-20; 19: 359-362