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Potential of labeling monoclonal antibodies for positron emission tomography and magnetic resonance imaging


, : Potential of labeling monoclonal antibodies for positron emission tomography and magnetic resonance imaging. Acta Radiologica. Supplementum 374: 129-133

Monoclonal antibodies have been suggested as potential agents for diagnosing tumors and other disorders due to the great specificity of monoclonal antibodies. Two new approaches to labeling of monoclonal antibodies involve the attachment of paramagnetic compounds which can be used with nuclear magnetic resonance (MR) imaging or attaching to a positron-emitting radionuclide for use with positron emission tomography (PET). In the case of agents for MR imaging, significantly greater amounts of compound need to be administered than in the radionuclidic case. The limitations of this technique when attaching a large number of paramagnetic agents to a monoclonal antibody are evaluated and discussed. In the case of PET, several radionuclides are compared and contrasted and examples are given in animal models where significant uptake in target tissue is obtained in time frames suitable for imaging. The ultimate potential of these two modalities is evaluated.

US$29.90

PMID: 1966959


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Campbell, R.A.; Tummino, A.; Noskov, B.A.; Varga, I., 2016: Polyelectrolyte/surfactant films spread from neutral aggregates. We describe a new methodology to prepare loaded polyelectrolyte/surfactant films at the air/water interface by exploiting Marangoni spreading resulting from the dynamic dissociation of hydrophobic neutral aggregates dispensed from an aqueous dispe...

Okuda, K.; Kawaguchi, M.; Nakamura, Y.; Kawashima, T., 1969: Autopsy case of strongyloidiasis and the mechanism of protein loss. Naika. Internal Medicine 24(5): 963-968

Rutault, K.; Coin, D.; Vacheron, M.J.; Guinand, M.; Wallach, J.; Michel, G., 1992: Identification of a small epitope in domain Ib of Pseudomonas aeruginosa exotoxin A that elicits enzyme-neutralizing antibodies. A peptide corresponding to amino acids 392-404 of the amino acid sequence of Pseudomonas aeruginosa exotoxin A (the last 13 amino acids of domain Ib) was synthesized and coupled to thyroglobulin. The conjugate induced an antiserum in rabbits with...

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James, D.G., 1990: The Chianciano Conference to redefine chronic liver disease. Postgraduate Medical Journal 66(773): 163-165