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Protein kinase C isozyme expression in human leukemia-lymphoma cell lines--an immunocytochemical study

, : Protein kinase C isozyme expression in human leukemia-lymphoma cell lines--an immunocytochemical study. Hematological Oncology 10(6): 295-300

There have been an increasing number of reports describing a pivotal role for phosphorylation in cellular responses for cell differentiation and proliferation. We examined an immunocytochemical expression of protein kinase C(PKC) isozymes (type I, II, and III) in 22 leukemia-lymphoma cell lines. Of these cell lines, 21 expressed type II PKC and 17 showed the co-expression of both types II and III PKC in varying degree. The cell line without PKC activity showed far less [3H]-TdR uptake and no heterotransplantation in nude mice. Types II and III PKC appear to relate to cell proliferation in certain leukemia-lymphoma cell lines.


PMID: 1296930

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