geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Reaction of ortho-ortho-dimethylphenacyl-halides with formamide. Formation of 4(5)-(ortho-ortho-dimethylbenzoyl)imidazoles


, : Reaction of ortho-ortho-dimethylphenacyl-halides with formamide. Formation of 4(5)-(ortho-ortho-dimethylbenzoyl)imidazoles. Il Farmaco; Edizione Scientifica 33(5): 364-381

Reaction of 2,3,5,6-tetramethylphenacyl halides with formamide did not produce the expected 4(5)-(2,3,5,6-tetramethylphenyl)imidazole, but 4(5)-(2,3,5,6-tetramethylbenzoyl)imidazole (VII) was isolated as the major product together with 5-(2,3,5,6-tetramethylphenyl)oxazole (III), alpha-formylamino-2,3,5,6-tetramethylacetophenone (IV) and alpha-chloro-beta-amino-vinyl 2,3,5,6-tetramethylphenyl ketone (IX) as by-products. The corresponding mesitylene derivatives gave analogous results, whereas 4(5)-(2-methylphenyl)imidazole was obtained from 2-methylphenacyl bromide as expected according to the Bredereck's reaction. The structure of the isolated compounds were elucidated by element analysis, mass, I.R., U.V. and N.M.R. spectra, and by chemical reactivity.

US$29.90

PMID: 738454


Other references

Stemmler, I.; Lammel, G., 2010: Pathways of PFOA to the Arctic; variabilities and contributions of oceanic currents and atmospheric transport and chemistry sources. Perfluorooctanoic acid (PFOA) and other perfluorinated compounds are industrial chemicals in use for decades which resist degradation in the environment and seem to accumulate in polar regions. Transport of PFOA was modeled using a spatially resol...

Berezovskĭ, V.A.; Serebrovskaia, T.V., 1987: Ventilatory response to a hypercapnic stimulus as an index of the reactivity of the human respiratory system. Fiziologicheskii Zhurnal 33(3): 12-18

Polisson, R.P.; Gilkeson, G.S.; Pyun, E.H.; Pisetsky, D.S.; Smith, E.A.; Simon, L.S., 1996: A multicenter trial of recombinant human interferon gamma in patients with systemic sclerosis: effects on cutaneous fibrosis and interleukin 2 receptor levels. Objective. To evaluate the acute toxicity, potential efficacy, and effects on the soluble interleukin 2 receptor (sIL-2R) of recombinant human interferon gamma (rIFN-gamma) in patients with systemic sclerosis (SSc). Methods. A multicentered, pilot...

Anonymous, 1982: In memory of Pavel Petrovich Chinaev Medicinal entomologist.0. Meditsinskaia parazitologiia i parazitarnye bolezni 51(4): 90-91

Lubicz-Nawrocki, C.M.; Chang, M.C., 1978: The influence of the testis on the fertilizing life of spermatozoa in the ligated vas deferens of the golden hamster. Spermatozoa in the vas deferens of the hamster lost their fertilising capacity 3 days after ligation of the initial part of the duct and after 2 days if the testes were removed at the time of ligation. Sham ligation had no effect on the fertilisin...

Hubka, M.; Bàrdos, P.; Simkovic, I.; Smrecanskỳ, V., 1973: Intraoperative evaluation of the effectiveness of cardiosurgical corrections. Journal of Thoracic and Cardiovascular Surgery 66(2): 181-184

Shutt, D., 2014: Food production begins with your hands. Occupational Health & Safety 82(11): 36, 38-36, 38

Yoshida A., 1975: Glucose 6 phosphate dehydrogenase deficiency and inhibition by nadph a self contradictory argument. Science (Washington D C) 190(4210): 171-172

Carpenter, W.J.; Hepp, R.E., 1973: Consumer attitudes toward the purchase of floral products. The purpose of the study was to determine the attitudes of college age youth and the general public towards flowers and their use. Samplings of the residents of the greater Lansing, Michigan area and the 40,000 students at Michigan State Universit...

Bullard, R.W., 2011: Alkaline phosphatase and metastatic liver disease. Surgery 19: 379-382