+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Renin secretion by the spontaneously diabetic rat

, : Renin secretion by the spontaneously diabetic rat. Diabetes 35(3): 341-346

Renal function studies and measurements of in vivo plasma renin activity (PRA), kidney renin content, and renin secretion by isolated, perfused kidneys were performed in spontaneously diabetic and nondiabetic BioBreeding/Worcester (BB/W) rats. Diabetic animals evidenced hyperglycemia, glycosuria, and plasma volume expansion. After dietary sodium deprivation, plasma volume fell to levels equivalent to those of sodium-deprived, nondiabetic rats. Dietary sodium deprivation evoked a larger proportional increase in PRA among diabetic than nondiabetic animals, although PRA before sodium restriction was equivalent in the two groups. Basal renin release (RR) was higher from isolated, perfused kidneys from diabetic rats than from nondiabetic kidneys. Diabetic kidneys, moreover, displayed increased kidney renin content (KRC). By contrast, while isoproterenol (10(-5) M) stimulated a nearly fivefold increment in RR from nondiabetic, perfused kidneys, a negligible effect was observed in diabetic kidneys. The dose-response curve of renin secretion (as a proportion of total renal content) in response to isoproterenol was shifted downward. Hence, while KRC and spontaneous RR by isolated, perfused kidneys were increased, the increment in PRA with salt depletion and the renin-secretory response to isoproterenol in vitro were impaired. We propose that specific defects in renin secretion, in particular, the response to beta-adrenergic stimulation, may be operative in diabetes.


PMID: 3512345

Other references

Kanchan Singh; Subrata Sharma; Satrupa Rao, 2005: Modified protocol for varietal identification of linseed. Protein and esterase banding patterns have been modified and standardized for use in the identification of distinctness among linseed cultivars and as a marker in breeding programmes. For protein separation, presoaked linseed seeds were used and N...

Fouquet, M.Thiere, D.Latour, V.Rger, 1951: Case of circumscribed osteoporosis of the cranium. Journal de Radiologie, D'electrologie & Archives D'electricite Medicale 32(3-4): 438-440

Christian, R., 1977: Peak Park problems. Country life: 161 (4157) 486-488

Harada, T.Eresa, W.Itt, G.Rdon, 2013: Researching Transport Choices The Possibilities of ‘Mobile Methodologies’ to Study Life-on-the-Move. Personal transport choices are under increased government scrutiny as private cars are attributed with exacerbating carbon emissions. This paper appraises the value of mobile methodologies for researching transport choices through paying closer at...

Ren, H.; Wang, Y.; Chen, M-liang.; Yuan, Z-an.; Li, Y-ting.; Huang, P.; Hu, J-yu., 2015: Study on the epidemiological characteristics and incidence trend of scarlet fever in Shanghai, 2005-2012. To systemically analyze the epidemiological characteristics, molecular markers of circulating group A Streptococcus (GAS) isolates and the incidence trend of scarlet fever in Shanghai from 2005 to 2012 as well as to explore the practice of GAS iso...

Olson, N.R., 1982: Frontal sinus ablation. Archives of Otolaryngology 108(11): 749-749

Ippolito, T.L.; Blier, J.S.; Fox, T.T., 1954: Massive T-wave inversion. American Heart Journal 48(1): 88-94

Esmatjes, E.; Flores, L.; Vidal, M.; Rodriguez, L.; Cortés, A.; Almirall, L.; Ricart, M.J.; Gomis, Rón., 2004: Hypoglycaemia after pancreas transplantation: usefulness of a continuous glucose monitoring system. After pancreas transplantation (PTx) some patients report occasional symptoms of hypoglycaemia and at times, serious hypoglycaemia. Continuous blood glucose monitoring (CBGM) allows determination of the daily glucose profile and detection of unrec...

Walter J.E., 1980: A new snail in the lake of zurich switzerland potamopyrgus jenkinsi new record gastropoda prosobranchia. The prosobranch water snail P. jenkinsi (E. A. Smith, 1889) was found for the 1st time in Lake Zurich, Switzerland.

Okano T.; Yoneya S.; Muraoka K.; Kishi S.; Numaga T., 1985: Comparison of argon and krypton laser in the treatment of diabetic retinopathy. We compared the therapeutic effect of blue-green argon and red krypton lasers in simple and proliferative diabetic retinopathy. In 18 patients with similar degree of diabetic retinopathy in kind and intensity, one eye was treated with argon and th...