+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Reward versus performance in self-stimulation: electrode-specific effects of alpha-methyl-p-tyrosine on reward in the rat

, : Reward versus performance in self-stimulation: electrode-specific effects of alpha-methyl-p-tyrosine on reward in the rat. Journal of Comparative and Physiological Psychology 91(5): 962-974

The hypothesis that alpha-methyl-p-tyrosine (AMPT), an inhibitor of catecholamine synthesis, reduces brain stimulation reward was tested, using a measure of reward previously shown to be relatively unaffected by variables that alter performance but not reward. The rewarding effectiveness of stimulation was determined by the location of the sharp rise in the function relating running speed in an alley to the number of pulses received as a reward. For some electrodes, AMPT depressed self-stimulation performance (speed of running) without producing any sizable effect on the measure of reward (location of rise). For other electrodes, the rewarding effectiveness of the stimulation was greatly reduced by AMPT and restored by L-dopa. These opposing results could be repeatedly demonstrated on different electrodes in the same rat. The electrode-specific differential sensitivity to AMPT suggests neurochemically disparate substrates for reward.


PMID: 303649

Other references

Talmadge, Cornelia, A., 1986: College chemistry faculties. Analytical Chemistry 58(3): 468A-468A

Carson, C.F.; Riley, T.V., 2001: Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil. The identity, sources and composition of tea tree (Melaleuca alternifolia) oil are discussed, and earlier errors in the literature indicated. Reports of both therapeutic and allergenic effects are reviewed.

Avelar, W.M.; D'Abreu, A.; Coan, A.C.; Lima, Fício.Oliveira.; Guimarães, R.; Yassuda, C.L.; Oliveira, G.P.; Guillaumon, A.T.; Filho, A.A.; Min, L.L.; Cendes, F., 2016: Asymptomatic carotid stenosis is associated with gray and white matter damage. Cognitive deficits in patients with asymptomatic carotid stenosis have been reported. The ultimate mechanism of cognitive deficits remains unclear and might be related to subtle structural brain damage. The aim of the present study was to evaluate...

Von Der Hardt, P.; Jones, A.V.; Lecomte, C.; Tattegrain, A., 1994: Nuclear safety research The Phebus FP severe accident experimental program. Nuclear Safety 35(2): 187-205

Dorozynski, A., 1975: Focus on Africa. Global effort to combat tropical diseases. An intensive programme directed against 6 of the major tropical diseases (including schistosomiasis and filariasis) to be undertaken by the WHO with collaboration from IDRC is briefly outlined. Africa will be the focus of the initial effort.

Xia, Y.; Chen, S.; Wang, Y., 1999: RelB modulation of IkBa stability as a mechanism of transcription suppression of interleukin-1a (IL-1a), IL-1b, and tumor necrosis factor alpha in fibroblasts. Molecular and Cellular Biology 1): 88-96

Sansaricq S.E.S.; Goldstein F.B., 1984: Propionic acidemia a variant form. Pediatric Research 18(4 PART 2): 299A

Reaser, Jamie Kristine, 1997: Caudata Batrachoseps attenuatus Predation. Herpetological Review 28(2): 81

Dzhabbarov, I.S.; Popova, I.S., 1991: Meiosis in the course of microsporogenesis in varietal populations of spring diploid rye in Tajikistan. In a study of PMC meiosis in 3 varieties grown at 800, 1369 and 2500 m above sea level in Tajikistan, the frequency of disturbances was on average 8.9% at metaphase I, 10% at anaphase I, 8.6% at metaphase II, 10.3% at anaphase II and 5.4% at the t...

Gintsburg, A.L.; Anan'ina, I.V.; Tarasevich, I.Vladimirovna., 2008: Contribution of academician I.V. Tarasevich to domestic and world rickettsiology. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk: 3-5