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Roux-Y intestinal bypass for administration of sorbents in uremia


, : Roux-Y intestinal bypass for administration of sorbents in uremia. Kidney International. Supplement: S153-S159

In order to minimize interaction of sorbents with food and digestive secretions, an intestinal bypass was created for sorbent administration in normal and uremic rats (N = 18) and goats (N = 5). Two separate limbs of small intestine were fashioned, one for food absorption and one for sorbent function, which joined at a Roux-Y anastomosis before the cecum. Particulate sorbent suspensions were injected into the intestine via a cutaneous stoma, and were excreted with food wastes in the feces. In animals with normal kidneys, sorbent function was calculated from changes in fecal and urinary excretion. Nitrogen clearance by the intestinal bypass was 20 to 40% of normal renal clearance in rats and goats. Potassium clearance was 40% of normal renal clearance in rats, and over 100% in goats. Sorbent treatment in anephric animals caused serum urea nitrogen concentrations to stabilize at 210 mg/dl in rats, and 110 mg/dl in goats. Serum potassium concentrations stabilized at 4.5 mEq/liter in rats, and fell to 2 mEq/liter in goats. Water balance was maintained by producing a mild osmotic diarrhea. At least three substances which accumulate in renal failure--urea, potassium, and water--were removed in therapeutically significant amounts.

US$29.90

PMID: 278884


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Huan, S.Y.; Yang, C.H.; Chen, Y.C., 2000: Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy. Arsenic trioxide (As2O3) was recently identified as a very potent agent against acute promyelocytic leukemia (APL). Intravenous infusion of 10 mg As2O3 daily for one to two months can induce significant complete remission (CR) of APL, and there is...

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Kolff, W.J., 1961: Introduction to six short papers on the present status of clinical hemodialysis. Cleveland Clinic Quarterly 28: 1-2

Blus, L.; Stafford, C., 1980: Breeding biology and relation of pollutants to black skimmers and gull-billed terns in South Carolina. Special scientific report wildlife United States Dept of Interior Fish and Wildlife Service: (230)

Imamura, S., 1989: Proliferative disorders of mononuclear phagocyte system in dermatological field. Nihon Rinsho. Japanese Journal of Clinical Medicine 47(3): 633-637

Meiniger, J.V., 1980: Nursing a hazardous occupation. Tijdschrift Voor Ziekenverpleging 33(24): 1153-1156

Bauserman, S.C.; Hardman, J.M.; Schochet, S.S.; Earle, K.M., 1978: Pituitary oncocytoma. Indispensable role of electron microscopy in its identification. Two surgically resected pituitary adenomas that appeared to be chromophobe or poorly granulated acidophil adenomas by light microscopy were correctly identified as oncocytomas by electron microscopy. The tumor cells ahd markedly hyperplastic, mode...

Bau, C.A.; Kleu, M., 1936: Uber Fibrinolyse und Fibrinolysehemmung im Plasma im Verlauf des Scharlachs. In general, the blood-plasma from acute cases of scarlet fever showed only slight antifibrinolytic effect. This increased regularly during the disease, reaching a maximum from the 4th to the 10th week. The increase was greater in cases without, le...

Raja, J.; Kurucheve, V., 1998: Influence of plant extracts and buffalo urine on the growth and sclerotial germination of Macrophomina phaseolina. Cold and hot water extracts of garlic, Curcuma aromatica and ginger, and buffalo urine inhibited the mycelial growth of M. phaseolina in laboratory tests. The inhibition by these extracts was equivalent to that obtained using 0.1% carbendazim.

Cardinale, M.; Leiper, J.; Erskine, J.; Milroy, M.; Bell, S., 2006: The acute effects of different whole body vibration amplitudes on the endocrine system of young healthy men: a preliminary study. Whole body vibration (WBV) has been suggested as an alternative form of exercise producing adaptive responses similar to that of resistance training. Very limited information is available on the effects of different vibration parameters on anaboli...