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Sexual transmission of hepatitis C virus: cohort study (1981-9) among European homosexual men

, : Sexual transmission of hepatitis C virus: cohort study (1981-9) among European homosexual men. Bmj 301(6745): 210-212

To determine the prevalence, incidence, and persistence of positivity for antibodies to hepatitis C virus (anti-HCV) and the potential for sexual transmission of the virus. A cohort analysis covering 1981-9 comparing estimated cumulative incidences of and seroconversion rates for anti-HCV with those of hepatitis B core antibody (anti-HBc) and antibodies to the human immunodeficiency virus (anti-HIV). Copenhagen and Aarhus, Denmark. 259 Male members of a Danish homosexual organisation. Correlations of prevalence and incidence with a wide range of sexual lifestyle variables. Only four (1.6%) subjects were positive for anti-HCV in 1981. The estimated cumulative incidence of positivity for anti-HCV was 4.1% in 1984 (seroconversion rate during 1981-4 (2.5%)) and remained at 4.1% in 1989 (seroconversion rate nil during 1984-9). In contrast, positivity for anti-HBC rose from 44.0% in 1981 to 52.7% in 1984 (seroconversion rate 15.5%) and 58.8% in 1989 (seroconversion rate 12.9%), and that for anti-HIV rose from 8.8% to 24.0% (seroconversion rate 16.7%) and 30.1% (seroconversion rate 8.0%) respectively. Three anti-HCV positive patients seroreverted three to five years later. None of the anti-HCV positive subjects had had a transfusion and only one gave a past history of intravenous drug use. Variables in sexual lifestyle correlated with the presence of anti-HBc but not with that of anti-HCV. In contrast with hepatitis B virus and HIV, sexual transmission of hepatitis C virus seems to be a rare event. Furthermore, antibodies to the virus may become undetectable after several years.


PMID: 2118402

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Begum, M.Dilara.; Umemura, M.; Kon, S.; Yahagi, A.; Hamada, S.; Oshiro, K.; Gotoh, K.; Nishizono, A.; Uede, T.; Matsuzaki, G., 2007: Suppression of the bacterial antigen-specific T cell response and the dendritic cell migration to the lymph nodes by osteopontin. Osteopontin (OPN) has been reported to enhance the interferon (IFN)-gamma-producing Th1-type T cell response through the induction of interleukin (IL)-12 and the suppression of IL-10. We therefore investigated whether OPN could enhance Th1 induct...

Pollack, S.B.; Rosse, C., 1987: The primary role of murine bone marrow in the production of natural killer cells. A cytokinetic study. The normal steady state production of natural killer (NK) cells in the bone marrow and spleen was characterized with cytokinetic technics. We developed a protocol to enrich for NK cells in bone marrow and demonstrate that target binding can be use...

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Christensen, F.; Dam, H., 1956: Reproduction capacity of rats in relation to diet. 5. Absence of influence of high casein and addition of vitamin B12 on vitamin E deficient diets. Increasing the casein level from 20 to 40 per cent in a vitamin E-free diet fed to 60 young female rats had no effect on the reproductive capacity of the rats.

Li, Y.; Wu, J.; Jin, Z.; Hou, Y., 1998: Genetic polymorphism at D20S161 locus in Chinese populations. To understand the genetic relationship between different populations in China and to obtain the preliminary data on the genetic poly- morphisms of D20S161 in seven populations in China. EDTA-blood specimens were collected from 753 healthy unrelate...

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D.K.uijff B.; Verkleij A.J.; Leunissen Bijvelt J.; Van Echteld C.J.A.; Hille J.; Rijnbout H., 1982: Further aspects of the calcium dependent polymorphism of bovine heart cardio lipin. The influence of cations on the structure of aqueous dispersions of the sodium salt of bovine heart cardiolipin was investigated by binding experiments, 31P-NMR, freeze-fracture EM, small angle X-ray diffraction and batch calorimetry techniques. I...

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Platt J.P.; Kelley S.P.; Carter A.; Orozco M., 2005: Timing of tectonic events in the Alpujarride Complex, Betic Cordillera, southern Spain. Ar-Ar and fission-track dating from four low-grade sections in the Alpujarride Complex sheds light on the timing of the early contractional history of these high-pressure metamorphic units, and their subsequent exhumation during the early Miocene...

von Schweinitz, D.; Schmidt, D.; Fuchs, J.; Welte, K.; Pietsch, T., 1995: Extramedullary hematopoiesis and intratumoral production of cytokines in childhood hepatoblastoma. Extramedullary hematopoiesis is a characteristic feature of hepatoblastoma (HB). We investigated 15 HB to characterize intratumoral hematopoietic foci and to find clues to the pathophysiology of their formation. By conventional histology and immun...