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Skeletal response of ovariectomized rats to low and high doses of 17 beta-estradiol

, : Skeletal response of ovariectomized rats to low and high doses of 17 beta-estradiol. Bone and Mineral 14(3): 175-187

Recent studies indicate that the mode of action of estrogen in preventing bone loss due to ovarian hormone deficiency may vary with the dose of the hormone. In this study four groups of ovariectomized animals were maintained on a wide range of doses of 17 beta-estradiol to further determine the relationship of dose to the mechanism by which estrogen prevents ovarian hormone deficiency bone loss. Ovariectomy caused a significant decrease in bone density and cancellous bone volume at the proximal metaphysis of the tibia. The decrease was prevented in a dose-dependent manner by estradiol. The rate of bone apposition in cancellous bone in the proximal tibia was increased by ovariectomy, and inhibited in a dose-dependent manner by estradiol. Similarly, ovariectomy increased the excretion of urinary hydroxyproline, an index of the rate of bone turnover, and serum alkaline and tartrate-resistant acid phosphatase. The increases were prevented in a dose-dependent manner by estradiol. In addition, the very high dose of estradiol, but not the lower doses, caused a marked (50%) decrease in serum osteocalcin. Our interpretation of these findings is that the low to very high doses of estradiol used in this study decreased the progression of the bone loss due to ovariectomy by suppression of the rate of bone turnover that involved the depression of both osteoclastic resorption and osteoblastic bone formation.


PMID: 1932891

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Blanco, D.; Alloza, P.; Montes, A.; Ortiz, M.; López, P.; Vidal, F., 1992: Comparative study of vecuronium and atracurium at low doses in minor pediatric surgery under combined anesthesia. To compare, the time of onset and time of recovery of muscular blockade after use of half doses of vecuronium and atracurium, we studied 18 children ASA I who were proposed for short lasting pediatric surgery and combined anesthesia. Patients were...

Kaplan, P.M.; Turubiner, N.M., 1965: Afferent influences of the thyroid and adrenal glands on conditioned reflex activity in dogs Physiology and pathology of higher nervous activity. A conditioned reflex left and right sided stereotype to bell, light, and metronome stimuli was developed in dogs and reinforced by oral administration of meat-rusk powder into the corresponding cheek. Reactions were evaluated according to salivati...

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Stegniĭ, V.N., 1983: Inversion polymorphism of the malarial mosquito Anopheles messeae. IV. The stability of the frequency distribution of the inversions by species area. Distribution of the frequencies of inversions XL1, 2R1, 3R1, 3L1, from geographically widely separated 8 populations had been studied during a long period of time. The geographical inclines of distribution of inversions XL1, 3R1 (a longitudinal) a...

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Rossier Y.; Kiraly L.; Tripet J.P.; Zwahlen F., 1992: Quantitative analysis of tracer tests in karst aquifers; their use in water protection. Annales Scientifiques de l'Universite de Besancon, Memoire hors serie 11: 65-76

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Van Reeth, P.C., 1952: Subacute necrotic myelitis. L'encephale 41(3): 289-306

Alton, D.J.; McDonald, P., 1975: Neonatal radiology. Urinary obstruction in the neonatal infant. Radiologic Clinics of North America 13(2): 343-358

Kadobayashi, I.; Nakamura, M., 1974: Modification of visual, auditory, and somatosensory evoked responses in cortical primary receiving areas by nigral stimulation. Experientia 30(3): 260-262