geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sleep deprivation in the rat: XI. The effect of guanethidine-induced sympathetic blockade on the sleep deprivation syndrome


, : Sleep deprivation in the rat: XI. The effect of guanethidine-induced sympathetic blockade on the sleep deprivation syndrome. Sleep 13(3): 218-231

In earlier studies, rats totally deprived of sleep by a disk-over-water apparatus (TSD rats) had shown an increase in energy expenditure (EE) that could not be explained by increased motor activity or the metabolic expense of wakefulness. Excessive activation of a calorigenic mediator was a possibility, and norepinephrine-mediated sympathetic activation was the most likely candidate, because plasma norepinephrine (NE) levels had risen sharply in TSD rats. To determine whether this activation was necessary for increased EE in sleep deprived rats, the peripheral sympathetic blocking agent guanethidine (GU) was administered to six sleep-deprived (GD) rats and their yoked control (GC) rats. GU attenuated the increase in NE previously seen in TSD rats, but the increase in EE was not attenuated. Apparently, NE-mediated sympathetic activation was not critical for increased EE in sleep-deprived rats. On the other hand, plasma epinephrine (EPI) levels were significantly increased in GD (but not in GC) rats above those previously seen in TSD rats, suggesting the substitution of one calorigenic mediator for another in response to an abnormally elevated need for EE. Temperature data suggest that increased need for EE could arise from an elevated temperature setpoint and an inability to retain body heat. GD (but not GC) rats also showed other effects previously seen in TSD rats, including debilitated appearance; severe ulcerative and hyperkeratotic lesions on the tails and plantar surfaces; initially increased and later decreased body temperature; decreased plasma thyroxine; increased triiodothyronine-thyroxine ratio; and eventual death. Evidently, NE-mediated sympathetic activation was not critical to any of these effects, although a role for catecholamines cannot be ruled out.

US$29.90

PMID: 2356394


Other references

Weingarten Jean, 2000: Confinement of wastes injected below thawed permafrost; a 12 year update from the North Slope of Alaska. The main North Slope Class I industrial waste disposal facility has injected 12 million barrels into a permeable formation beneath the permafrost at 2000 feet. Initial concerns about fluid confinement were addressed by extensive field testing. Thi...

Sopka, S.; Brokmann, Jörg.Ch.; Rossaint, R.; Pirkl, A.; Beckers, S.K., 2009: Communication in special situations: a training programme with standardized patients for emergency medical physicians. Regulations for the post-graduate education of physicians deployed in the emergency medical system in Germany are existing, but unfortunately not standardised nationwide. Within the compulsory certification course "soft skills" are not i...

Hamilton, Kirk, 2003: Sustaining economic welfare: Estimating changes in total and per capita wealth. Genuine saving measures the real change in total wealth, factoring in the depreciation of produced assets, depletion of natural resources, pollution damages, and expenditures on education. This paper presents a theoretical framework for measuring...

Havel, R.J., 1977: Classifications of the hyperlipidemias. Annual Review of Medicine 28: 195-209

Malenkov, A.G.; Filimonov, D.A.; Kolotygina, I.M.; Kolotygina, L.M.; Masalov, V.P., 1988: Thermal and electric conductivity in the Zakharin-Head areas of the skin in the normal state. Fiziologiia Cheloveka 14(4): 586-591

Fu, X.; Wan, S.; Lyu, Y.Lisa.; Liu, L.F.; Qi, H., 2008: Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. DNA damage such as double-stranded DNA breaks (DSBs) has been reported to stimulate mitochondrial biogenesis. However, the underlying mechanism is poorly understood. The major player in response to DSBs is ATM (ataxia telangiectasia mutated). Upon...

Tatsumi, K.; Muto, S.; Ikeda, K.; Orimo, S-Ichi., 2012: Chemical Bonding of AlH₃ Hydride by Al-L 2,3 Electron Energy-Loss Spectra and First-Principles Calculations. In a previous study, we used transmission electron microscopy and electron energy-loss (EEL) spectroscopy to investigate dehydrogenation of AlH₃ particles. In the present study, we systematically examine differences in the chemical bonding state...

Schenk, K.D.; Michaelis, A.; Sapiano, T.Nelson.; Brown, L.; Weiss, E., 2010: Improving the lives of vulnerable children: implications of Horizons research among orphans and other children affected by AIDS. From 1997 through 2007, the Horizons program conducted research to inform the care and support of children who had been orphaned and rendered vulnerable by acquired immunodeficiency syndrome in sub-Saharan Africa. Horizons conducted studies in Ken...

Giuliani, P.; Ballerini, P.; Ciccarelli, R.; Buccella, S.; Romano, S.; D'Alimonte, I.; D.A.imonte, I.; Poli, A.; Beraudi, A.; Peña, E.; Jiang, S.; Rathbone, M.P.; Caciagli, F.; D.I.rio, P., 2012: Tissue distribution and metabolism of guanosine in rats following intraperitoneal injection. Guanosine has long been known as an endogenous purine nucleoside deeply involved in the modulation of several intracellular processes, especially G-protein activity. More recently, it has been reported to act as an extracellular signaling molecule...

Williams, C.L., 1980: Primary prevention of cancer beginning in childhood. Preventive Medicine 9(2): 275-280