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Solubility and partitioning. IX: Solubility of hydantoins in water

, : Solubility and partitioning. IX: Solubility of hydantoins in water. Journal of Pharmaceutical Sciences 77(6): 518-522

An expression for estimating the aqueous solubility of weak electrolytes under different conditions of temperature and pH has been proposed in a previous publication. The expression, based on the additivity of free energy, separates solubility into three independent contributions. In the present work, the equation is tested with a different set of 18 solutes within the range of temperature of 20 to 50 degrees C and of pH of 1 to 10. The results show that the theoretical relationship between aqueous solubility and the three independent contributions used in the equation is in excellent agreement with the experimental data.


PMID: 3171932

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