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Some basic aspects of reversible inhibitors of monoamine oxidase-A

, : Some basic aspects of reversible inhibitors of monoamine oxidase-A. Acta Psychiatrica Scandinavica. Supplementum 360: 7-12

A novel class of antidepressants is emerging with considerable therapeutic potential: reversible inhibitors of monoamine oxidase type A (RIMA). Moclobemide (Aurorix) is a representative RIMA. It is a fully and rapidly reversible inhibitor of MAO-A with a correspondingly intermediate duration of action in vivo. It is free of hepatotoxicity and produces a much weaker potentiation of the tyramine pressor effect than the classical irreversible MAO inhibitors. Interaction of MAO inhibitors and monoamine reuptake inhibitors with tyramine is discussed on the basis of experiments in conscious rats. The issue of tyramine content of foods and beverages has been reinvestigated and its relevance for treatment with RIMA antidepressants is discussed. Recently observed antihypoxic (neuroprotective) effects of moclobemide suggest new indications for this compound.


PMID: 2248079

Other references

Hook E.B., 1982: The natural histories of fetuses with chromosome abnormalities during late gestation and implications for the theories of relaxed selection at older maternal ages. Teratology 25(2): 50A-51A

Singleton, G.R.; Brown, P.R.; Jacob, J.; Aplin, K.P., 2007: Unwanted and unintended effects of culling: A case for ecologically-based rodent management. In this study, the ecological effects of culling programs are considered in the context of rodent pest management. Despite the escalation of rodent problems globally, over the past quarter of a century there have not been many new developments in...

Zwingli, H., 1982: Overproduction in the fruit industry Switzerland.1. Agrartechnischer Fortschritt und moderne Landwirtschaft in Zeiten begrenzter Absatzmarkte: Anlass funfzigjahrigen Bestehens der Kantonalen Landwirtschaftlichen Schule Flawil SG 1932-1982 von HW Popp und EW Alther: 2

Myren, J., 1966: A comparison between biopsy- and cytology-findings and the results of some routine laboratory tests in the diagnosis of liver disease. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum 92: 173-174

Kuang, Y.L., 1982: Mesocaval end-to-side shunt in the management of postoperative bleeding in portal hypertension. Zhonghua Wai Ke Za Zhi 20(3): 152-153

Poblano, A., 1991: Neurosciences and philosophy. The goal of this paper is to show the paralelism between the objectives of both, neurosciences and philosophy. First, a historical review of the common works on both fields of study is made; next, the implications of the brain-mind relationship an...

Greenwood, J.A.; Murphy-Ullrich, J.E., 1998: Signaling of de-adhesion in cellular regulation and motility. Adhesion is a process that can be divided into three separate stages: (1) cell attachment, (2) cell spreading, and (3) the formation of focal adhesions and stress fibers. With each stage the adhesive strength of the cell increases. De-adhesion can...

Woolley, A.S., 2003: 100 years of servitude. American Journal of Nursing 103(11): 60-60

Petrov, P.P.; Vakhedi, A.S., 1987: Structure of eye morbidity in hospitalized patients at the National Institute of Eye Diseases of the Democratic Republic of Afghanistan. Vestnik Oftalmologii 103(4): 66-70

Anvari M.; Malbert C.; Taylor M.; Sgro R.; Horowitz M.; Jamieson G.G., 1992: Loxiglumide abolishes the effects of intraduodenal oleic acid on gastric motility and emptying. Gastroenterology 102(4 PART 2): A418