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Some problems in the laboratory findings in multiple myeloma

, : Some problems in the laboratory findings in multiple myeloma. Nihon Ketsueki Gakkai Zasshi 52(8): 1273-1278

The clinical usefulness of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) levels in serum and pathogenetic mechanism of hypoalbuminemia and hypocholesterolemia in multiple myeloma (MM) were investigated. In cases of MM with a history of pathological fracture, the level of serum ALP was significantly higher than normal. Thus, elevated ALP in MM patients may be an indicator of the occurrence of a pathological fracture within the past 2 months. The levels of serum LDH in about 80% of the MM patients were within normal limits despite the presence of a malignant tumor. These patients showed a normal pattern of isoenzymes and more mature types according to the Greipp classification. In contrasts, the patients with elevated serum levels of LDH showed the tumor pattern of the isoenzymes and the plasmablastic type. The total cholesterol concentration was correlated with the total protein levels and the serum cholinesterase. These findings were the same as those in patients with nephrotic syndrome and polyclonal hypergammaglobulinemia without liver dysfunction. These results suggest that the decreased cholesterol in MM is due to a reduction in the synthesis of albumin in the liver.


PMID: 2698042

Other references

Sakabe, N., 1970: Plans for the construction of sound-proof rooms and accessary equipment. Jibi Inkoka Otolaryngology 42(12): 1029-1037

Morgan K.S.; Asbell P.A.; May J.G.; Loupe D.N.; Kaufman H.E., 1982: Surgical and functional results of pediatric epi keratophakia. Investigative Ophthalmology & Visual Science 22(3 SUPPL): 201

Feijó, A.; D.R.cha, Pício.Adriano.; Althoff, S.Luiz., 2016: New species of Histiotus (Chiroptera: Vespertilionidae) from northeastern Brazil. Histiotus are vespertilionid bats endemic to South America, easily recognized by its very long ears. During a twelve-month bat inventory in northeastern Brazil, eleven specimens of Histiotus were collected with a unique combination of characters t...

Harvey, Mark, S., 2001: New cave-dwelling schizomids (Schizomida: Hubbardiidae) from Australia. Six new schizomid species are described from caves in Western Australia. Draculoides julianneae sp. nov. is restricted to a single cave on the western coastal regions of Cape Range peninsula, whereas D. brooksi sp. nov. is only known from a boreho...

Vernie, F.; Quere, G.; Pujol, J.Y.; Hirono, Y., 1978: What is alloxydim-sodium?. Chemistry and properties of alloxydim-sodium (2-[1-(N-allyloxyamino)butylidene]-4-methoxycarbonyl-5,5-dimethylcyclohexane-1,3-dione) are presented briefly together with a review of its toxicology, degradation, mode of action and a summary of susce...

Thal, W., 1964: Pseudocroup From Unrecognized Tracheal Foreign Bodies. Das Deutsche Gesundheitswesen 19: 1264-1267

Kowitz, A., 1984: Dentists of Chicago before the Great Fire. Bulletin of the History of Dentistry 32(2): 126-130

Thevenot C.; Come D., 1974: Correlations between the cotyledons and the axis of the apple embryo during the cessation of dormancy and germination. Revue de Cytologie et de Biologie Vegetales 37(3/4): 209-216

Bulatov, V.P.; Moroz, T.B.; Zakirova, F.I., 1991: The use of food fibers in the treatment of biliary system lesions in children. Lipid peroxidation was studied in children with biliary tract diseases. The data on the activation of lipid peroxidation have permitted the authors to use and recommend wheat bran as an antioxidant in the treatment of children with biliary tract d...

Schmidt, M.; Varsányi, M.; Thieleczek, R.; Heilmeyer, L.M., 1993: Identification of a new 80 k isoform of phosphatidylinositol 4-phosphate 5-kinase from bovine brain. Phosphatidylinositol 4-phosphate 5-kinase is associated with bovine brain microsomes to an extent of approximately 65% of the total cellular enzyme activity. This membrane-associated kinase activity can be solubilized with Triton X-114. Following...