+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Specific HLA-DQB and HLA-DRB1 alleles confer susceptibility to pemphigus vulgaris

, : Specific HLA-DQB and HLA-DRB1 alleles confer susceptibility to pemphigus vulgaris. Proceedings of the National Academy of Sciences of the United States of America 86(16): 6215-6219

The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the serotypes HLA-DR4 and HLA-DRw6. Based on nucleotide sequence and oligonucleotide probe analysis of enzymatically amplified DNA encoding HLA-DR beta chain (HLA-DRB) and HLA-DQ beta chain (HLA-DQB; henceforth HLA is omitted from designations), we showed previously that the DR4 susceptibility was associated with the Dw10 DRB1 allele [encoding the mixed lymphocyte culture (MLC)-defined Dw10 specificity]. The DRw6 susceptibility similarly was shown to be associated with a rare DQB allele (DQB1.3), which differed from another nonsusceptible allele by only a valine-to-aspartic acid substitution at position 57. Given the linkage disequilibrium that characterizes HLA haplotypes, it is difficult to assign disease susceptibility to a specific locus rather than to a closely linked gene(s) on the same haplotype. To address this problem, we have analyzed all of the polymorphic loci of the class II HLA region (DRB1, DRB3, DQA, DQB, and DPB) on the DRw6 haplotypes in patients and controls. In 22 PV patients, 4 different DRw6 haplotypes were found that encode the same DQ beta chain (DQB1.3) but contained silent nucleotide differences at the DQB locus as well as coding sequence differences in the DQA and DRB loci. These results, obtained by using a method for allele-specific polymerase chain reaction amplification, strongly support the hypothesis that the allele DQB1.3 confers susceptibility. This DQB allele is correlated with the MLC-defined Dw9 specificity and is associated with two different DRB1 alleles (the common "6A" associated with DRw13 and the rare "6B" associated with DRw14). Since 86% (19 of 22) of DRw6+ patients contain the DQB1.3 allele (vs. 3% of controls), whereas 64% (14 of 22) contain the DRB1 allele 6B (vs. 6% of the controls), we conclude that most of the DRw6 susceptibility to PV can be accounted for by the DQ beta chain.


PMID: 2503828

Other references

Young Brian; Jantaranipa Werapon, 1970: The discovery of upper Palaeozoic fossils in the Phuket series of peninsular Thailand. Trilobites, bryozoans, mollusks, other poorly preserved or indeterminate invertebrate material, evidence for Devonian-Permian age of upper Phuket group.

Sappington, N., 1997: Bringin em down. Arbor age 17(9): 14

Armengol, S.; Manzano, M.; Bea, S.A.; Martínez, S., 2017: Identifying and quantifying geochemical and mixing processes in the Matanza-Riachuelo Aquifer System, Argentina. The Matanza-Riachuelo River Basin, in the Northeast of the Buenos Aires Province, is one of the most industrialized and populated region in Argentina and it is worldwide known for its alarming environmental degradation. In order to prevent further...

Aurich, H.; Pham, D.Thoai.; Wirbelauer, C., 2011: Biometric evaluation of keratoconic eyes with slit lamp-adapted optical coherence tomography. To evaluate slit lamp-adapted optical coherence tomography for morphological imaging and morphometrical measurements in keratoconic eyes. Using slit lamp-adapted optical coherence tomography, we examined 32 eyes of 20 consecutive patients with ker...

Kiss, E., 1962: Application of the provocative method in testing the susceptibility of Flax vars. to C. linicola. Inoculation tests in the field (1954-56) showed that the large-seeded oil flax vars, were more susceptible to infection by C. linicola . The resistance of several vars. was increased by selection. The oil seed vars, K39(A) and La Estanzuela 3030,...

Christ, T.; Schier, M.; Brattström, A.; Muth, G.; Hartmann, A.; Dobrev, D.; Ravens, U., 2002: Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test. The Inos2 DDDR pacemaker senses unipolar intracardiac impedance signals for adapting heart rate to meet the haemodynamic needs of physical activity. Theoretically, such pacing devices could be limited by positive feedback since increase in beating...

Novin Baheran A.; Mulvey R.K., 1977: Electro shock anti convulsant activity and brain acetyl choline alterations in mice treated with select benzodiazepines. Pharmacologist 19(2): 214

Cichowicz Artur, 1993: Expert system for seismic hazard analysis. Institution of Mining and Metallurgy, Transactions, Section A: Mining Industry 102: 173-180

Fischer, J.B.; Cho, A.K., 1983: Release of norepinephrine from organ-cultured superior cervical ganglia: effects of the norepinephrine uptake inhibitor xylamine. After preloading with [3H]norepinephrine (NE), organ-cultured superior cervical ganglia released increased amounts of [3H]NE when incubated with depolarizing K+ concentrations, tyramine or amphetamine. K+-induced release was Ca++-dependent, wherea...

Spencer, J.D.; Stahl, C.A.; Gaines, A.M.; Kendall, D.C.; Yi, G.F.; Frank, J.W.; Berg, E.P.; Jones, D.J.; Allee, G.L., 2002: The efficacy of Paylean addition to late-finishing swine diets in a controlled cycling hot environment. Journal of Animal Science 80(Supplement 2): 78