+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Stability of amphotericin B in 5% dextrose injection at concentrations used for administration through a central venous line

, : Stability of amphotericin B in 5% dextrose injection at concentrations used for administration through a central venous line. American Journal of Hospital Pharmacy 48(2): 283-285

The stability of amphotericin B in 5% dextrose injection was studied at concentrations used for administration through a central venous line. Amphotericin B 60, 80, and 100 mg was diluted in 50 mL of 5% dextrose injection; final mean +/- S.D. concentrations after adjustment for total volume were 0.92 +/- 0.01, 1.20 +/- 0.03, and 1.40 +/- 0.03 mg/mL, respectively. For each concentration, six admixtures were prepared; of these, three were stored at 25 degrees C and three at 6 degrees C. Amphotericin B concentration was tested at 0, 4, 12, 24, and 36 hours by stability-indicating high-performance liquid chromatography. The admixtures were inspected visually at each time point for precipitation, turbidity, gas formation, and color change, and the pH was measured. Concentrations of amphotericin B remained within 3% of initial concentrations at each time point at both storage temperatures. No precipitation, turbidity, gas formation, or color change was observed, and no changes in pH were measured. Amphotericin B in 5% dextrose injection was stable at concentrations of 0.92, 1.20, and 1.40 mg/mL when stored at 6 and 25 degrees C for up to 36 hours.


PMID: 2003501

Other references

Yousem, D.M.; Geckle, R.J.; Bilker, W.B.; McKeown, D.A.; Doty, R.L., 1996: Posttraumatic olfactory dysfunction: MR and clinical evaluation. PURPOSE: To evaluate the sites of injury in patients with posttraumatic olfactory deficits and to compare damage with findings on clinical olfactory tests. METHODS: Twenty-five patients with posttraumatic olfactory dysfunction were examined by mea...

Sokolov, V.E. .; Kulikov, V.F. ., 1995: Ecological investigation in Moscow and the Moscow Region Animals. Unknown

Schumaker, Jack, F., 1983: Eating patterns in Thailand. A survey of 221 adults (42% female; 58% male) was conducted in Thailand to assess reasons for low obesity incidence relative to the US. While 72% said that they were inclined to overeat, only 3% were overweight. This observation could not be attri...

Castellano, M.; Muiesan, M.L.; Beschi, M.; Rizzoni, D.; Cinelli, A.; Salvetti, M.; Pasini, G.; Porteri, E.; Bettoni, G.; Zulli, R.; Agabiti-Rosei, E., 1996: Angiotensin II type 1 receptor A/C1166 polymorphism. Relationships with blood pressure and cardiovascular structure. The angiotensin II type I (AT-1) receptor has a key role in mediating the vasoconstrictor and growth-promoting effects of angiotensin II. It has been reported that a polymorphism of the AT-1 receptor gene (an A/C transversion at position 1166) may...

Liu, J.; Liu, B.; Zhu, Z.; Chen, L.; Hu, J.; Xu, M.; Cheng, C.; Ouyang, X.; Zhang, Z.; Ruan, J.; He, S.; Liu, L.; Gu, M.; Chen, H., 2017: Modified timing characteristic of a scintillation detection system with photonic crystal structures. It is intuitively expected that an enhanced light extraction of a scintillator can be easily achieved by photonic crystal structures. Here, we demonstrate a modified timing characteristic for a detection system induced by enhanced light extraction...

Asthana, S., 1995: Variations in poverty and health between slum settlements: contradictory findings from Visakhapatnam, India. Whilst much work has been done to highlight the plight of the urban poor in less developed countries, little information exists about differences in health between poor urban areas. This paper describes environmental and other health hazards in fi...

Gerbermann, A.; Wiegand, C.; Cuellar, J., 1975: Acreage of vegetables in Hidalgo County in 1972 and 1973. Journal of the Rio Grande Valley Horticultural Society: 9 71-79

Hawkins, J.A.; Shilling, C.W.; Hansen, R.A., 1934: Velocity of blood flow as influenced by exercise and increased air pressure. Velocity of blood flow was determined on subjects at rest and following exercise at 1 and 6 atm. absolute. Velocity of blood flow, pulse and pulse pressure increased following exercise at one atmosphere. Exercise under increased air pressure does...

Navarra; Nielsen; Nunes; Teixeira, 1996: Intrinsic charm component of the nucleon. Physical Review. D, Particles and Fields 54(1): 842-846

Sieracki, C.A., 1993: Organizational liability prevention: automated profiles. The key to successful nursing management is maintenance of efficient records and productive operations. Only through automating educational profiles for competency and licensure renewal can nursing administration provide instantaneous information...