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Studies on vasoocclusive crisis of sickle cell disease. I. Effect of pentoxifylline


, : Studies on vasoocclusive crisis of sickle cell disease. I. Effect of pentoxifylline. Journal of Medicine 10(6): 445-456

A method was developed to induce and continuously monitor vasoocclusive crisis of sickle cell disease in non-human primates. Pentoxifylline, a phosphodiesterase inhibitory agent, showed significant preventive effect. This may be based on its ability to increase intracellular cAMP levels and consequently to decrease platelet aggregation and to increase red cell deformability.

US$29.90

PMID: 299453


Other references

Zimmerman, R.D.; Russell, E.J.; Leeds, N.E.; Kaufman, D., 1980: CT in the early diagnosis of herpes simplex encephalitis. Herpes simplex is the most common cause of sporadic viral encephalitis. The recent development of specific antiviral chemotherapeutic agents offers new optimism for patients with this disorder if therapy is begun on or before the fifth day of the...

Walwyn, D., 2013: Patents and profits: A disparity of manufacturing margins in the tenofovir value chain. Registered in 2001, tenofovir disoproxil fumarate (TDF) has quickly become a mainstay of first line regimens for the treatment of HIV. Initially only available in developed countries at a cost of US$5 000 per person per year (ppy), Gilead's A...

Chapleur Y.; Moufid N., 1989: Radical cyclization of some unsaturated carbohydrate derived acetals. Journal of the Chemical Society Chemical Communications (1): 39-40

Kamicker, B.J.; Mann, D.D.; Hassfurther, R.L.; Illyes, E.F.; Quach, R.; Earley, D.L.; George, D.M.; Bertsche, C.D.; Norcia, L.J.L.; Hayashi, S.F.; Nowakowski, M.A.; Espanol, E.E.; Bunger, A.; St, 2003: Therapeutic and prophylactic activity of azalides and triamilides in treatment of bovine respiratory disease. Journal of Veterinary Pharmacology & Therapeutics 26(Supplement 1): 234, August

Simakov, V.N.; Nizova, A.A., 1966: Alteration of properties of light derno-podzolic soils under the influence of clay. Claying sandy-loamy soil increased potato and barley yields, increased pH, decreased hydrolytic and exchange acidities, and increased total exchangeable bases and buffering capacity, N-NH4content and nitrifying capacity, and mobile-K content.

Birova-Volosinovieova, V., 1967: Neue Art einer Plathelminthe Dilepis? spasskayae sp. n. (Delepididae) aus dem Eichelhaher (Garrulus glandarius L.). Biologia, Bratisl.: 22: 823-830

Schoonmaker J.N.; Bergman K.S.; Steiner R.A.; Karsch F.J., 1982: Estradiol induced luteal regression in the rhesus monkey macaca mulatta evidence for an extraovarian site of action. Studies were performed to test the hypothesis that estradiol is a physiologic luteolysin in the rhesus monkey and that it acts within the ovary containing the corpus luteum. Samples of peripheral blood were collected every 4 h and analyzed for var...

Brody, M.; Golden, M.M.; Lichtman, H.S., 1965: Experience with small group seminars for practicing physicians. Metholdology in teaching psychiatry needed in general practice must be geared to adult physicians. Needs of the student precede those of the teacher. Teaching must relate to student experience and demonstrate theory with actual experience and fact...

Allotey, P.; Yasin, S.; Tang, S.; Chong, S.Lin.; Cheah, J.Chee.Ho.; Reidpath, D.D., 2014: Universal coverage in an era of privatisation: can we guarantee health for all?. Bmc Public Health 12 Suppl 1: S1-S1

Graves, J.D.; Craxton, A.; Clark, E.A., 2004: Modulation and function of caspase pathways in B lymphocytes. During their development, B-lineage cells are selected to mature, to die, to divide, or to survive and wait, ready to respond to external signals. The homeostatic balance between growth, death, and survival is mediated by signaling pathways throug...