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Synthesis of an analogue of tabtoxinine as a potential inhibitor of D-alanine:D-alanine ligase (ADP forming)


, : Synthesis of an analogue of tabtoxinine as a potential inhibitor of D-alanine:D-alanine ligase (ADP forming). Journal of Medicinal Chemistry 32(1): 165-170

The design and synthesis of a potential inhibitor of D-alanine:D-alanine ligase (ADP forming) (EC 6.3.2.4) are described. This enzyme, which catalyzes the second step in the biosynthesis of bacterial peptidoglycan, is believed to generate D-alanyl phosphate as an enzyme-bound intermediate. With tabtoxinine, a potent inhibitor of glutamine synthetase, as a model, beta-lactams 9R and 9S were synthesized as potential precursors of a D-alanyl phosphate mimic.

US$29.90

PMID: 2562853


Other references

Anon, 1972: Meeting of the sama utmb national student research forum university of texas medical branch galveston texas usa april 20 22 1972. Texas Reports on Biology & Medicine 30(2): 195-247

Seo, J.; Gordish-Dressman, H.; Hoffman, E.P., 2006: An interactive power analysis tool for microarray hypothesis testing and generation. Motivation: Human clinical projects typically require a priori statistical power analyses. Towards this end, we sought to build a flexible and interactive power analysis tool for microarray studies integrated into our public domain HCE 3.5 softwar...

Fenyes, A., 1912: Remarks on Gnypeta Thoms. (Staphylinidae Coleoptera). Canadian Entomologist, 44 105-112

Gillbro T.; Sandstrom A.; Spangfort M.; Sundstrom V.; Van Grondelle R., 1988: Excitation energy annihilation in aggregates of chlorophyll a b complexes. Time-resolved picosecond absorption measurements were performed on aggregates of the light-harvesting chlorophyll (Chl) a/b complexes from spinach thylakoids. Various of the intensity of the exciting laser pulse showed that efficient excitation an...

Scioscia, M.; Nigro, M.; Montagnani, M., 2014: The putative metabolic role of d-chiro inositol phosphoglycan in human pregnancy and preeclampsia. Immunological alterations, systemic inflammation, endothelial dysfunction, and insulin resistance are prominent features of preeclampsia, although the reciprocal relationship between them is poorly understood. The metabolic syndrome that occurs du...

Kutty, M.K.; Bau, K., 1969: Maduramycosis in a Chinese in West Malaysia. Medical Journal of Malaya 24(2): 151-153

Langston Charles A., 1991: Broadband wave propagation in the central United States. Seismological Research Letters: , Pages 32. 1991.

E.Q.esni, F.E.M.; Salwa ; Gaweesh, S.M.; Korayem, A.M.; Osman, H.A., 1992: Effect of weed control on soyabean associated weeds and plant parasitic nematodes. A field study was carried out on a loamy soil at Antrees, Giza, to investigate the effect of pre-em. pendimethalin (50% EC) at 1.7 litres/feddan and hand hoeing, 25 + 55 days after sowing, on weeds of soyabean cv. Clark, soyabeans yields and yield...

Minkovitz, C.S.; Chandra, A.; Solomon, B.S.; Sanders, L.M.; Grason, H.A.; Carraccio, C., 2007: Factors influencing community pediatrics training in residency. The current study suggests the need for routine post-discharge surveillance to improve reliability on surgical site infection incidence rates. Surveillance only during hospitalization may not provide precise data on the incidence of surgical site...

Natorp, O., 1931: Beitrag zur Kenntnis der Kleider von Plectrophenax nivalis nivalis (L.). Jerlin: 338-346