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The X-ray crystal structure of 4-diphenylcarbamyl-N-methyl-piperidine methobromide (the carbamate analogue of 4-DAMP methiodide)

, : The X-ray crystal structure of 4-diphenylcarbamyl-N-methyl-piperidine methobromide (the carbamate analogue of 4-DAMP methiodide). British Journal of Pharmacology 98(2): 425-428

1. Crystals of 4-diphenylcarbamyl-N-methylpiperidine methobromide contain 2 conformers, one with the ester group equatorial and the other with the ester group axial to the piperidine ring. 2. In both conformers and diphenylcarbamyl nitrogen is trigonally substituted and flat compared with the tetrahedral substitution of the corresponding carbon atom in 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) methiodide. 3. The low activity and selectivity of the carbamate at muscarinic receptors is comparable with that of compounds containing only one phenyl ring, e.g. phenylacetyl-N-methyl piperidine methiodide or phenylacetylcholine. It is suggested that the high affinity of 4-DAMP metho-salts and their selectivity depend upon interactions with groups arranged in three dimensions and that the trigonal arrangement about the nitrogen atom in the carbamate makes it impossible for both benzene rings to interact at once.


PMID: 2819329

Other references

Pikuz, S.S.; Sebiakin, I.L., 1996: Model systems based on the lipid-porphyrin assemblies and lipoproteins in biochemical studies. Reviewed are the modern state and prospects of using lipid-porphyrin assemblies and lipoporphyrins to study fine functional mechanisms of complex biological systems and to solve applied problems in biochemistry and medicine. Data on the interactio...

Palma, R.Eduardo.; Gutiérrez-Tapia, P.; González, J.F.; Boric-Bargetto, D.; Torres-Pérez, F., 2017: Mountaintops phylogeography: A case study using small mammals from the Andes and the coast of central Chile. We evaluated if two sigmodontine rodent taxa (Abrothrix olivacea and Phyllotis darwini) from the Andes and Coastal mountaintops of central Chile, experienced distributional shifts due to altitudinal movements of habitat and climate change during a...

Cunat, J.S.; Dunne, M.G., 1985: Pelvic haematocele in ruptured ectopic pregnancy simulating uterine enlargement. Rupture of an ectopic pregnancy may result in the formation of a pelvic haematocele. Four cases are presented in which the haematocele appeared as a solid or complex mass of coarse echoes on ultrasound examination and was indistinguishable from th...

Gordon, W.L., 1960: Is Nectria haematococca Berk, and Br. the perfect stage of Fusarium oxysporum Schl. forma pisi (Lindf.) S. and H.?. Nature 186: 903-903

Ward Peter L., 1992: SUDS; the Seismic Unified Data System. Eos, Transactions, American Geophysical Union 73(35): 380

Agarwel, S.L.; Bhargava, V.; Jadhav, J.H., 1966: Effect of syrosingopine on the acetylcholine content in albino rats. Indian Journal of Physiology and Pharmacology 10(4): 166-167

Sato, D.; Yasuhara, Y.; Ochiai, M.; Ashida, M., 1995: On the heterogeneity of prophenoloxidase activating enzyme from cuticle of the silkworm, Bombyx mori. Zoological Science (Tokyo) 12(SUPPL ): 111

Ishida, A., 1982: Behaviour of Horia tosana Kono Meloidae, Coleoptera. Gensei, 42: 1-11

Burkhart, H.M., 2017: Simulation in congenital cardiac surgical education: We have arrived. Journal of Thoracic and Cardiovascular Surgery 153(6): 1528-1529

Gao Ning; Wen BoHai; Niu DongSheng; Qiu Ling; Chen MeiLing, 2004: Cloning and expression of gene fragment encoding the C region of 120kDa surface antigen of Rickettsia prowazekii in E. coli. A gene fragment encoding the C region of a 120 kDa surface antigen was amplified from the genome of Rickettsia prowazekii by polymerase chain reaction. The gene fragment was cloned into prokaryotic expression of vector pQE30. Escherichia coli cell...