+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The clinical and epidemiological profile of Lyme neuroborreliosis in Denmark 1985-1990. A prospective study of 187 patients with Borrelia burgdorferi specific intrathecal antibody production

, : The clinical and epidemiological profile of Lyme neuroborreliosis in Denmark 1985-1990. A prospective study of 187 patients with Borrelia burgdorferi specific intrathecal antibody production. Brain 115: 399-423

This prospective study reports the clinical and epidemiological features of 187 consecutive patients with neuroborreliosis recognized in Denmark over the 6-yr period, 1985-1990. Only patients with intrathecal Borrelia burgdorferi specific antibody synthesis were included. In 1990 regional incidences varied between 5.7 and 24.1 per million. Ninety-four percent of the patients had early (second stage) neuroborreliosis. The most common manifestation was a painful lymphocytic meningoradiculitis (Bannwarth's syndrome) either with paresis (61%) or as a radicular pain syndrome only (25%). Central nervous system (CNS) involvement in early neuroborreliosis was rare; 4% had signs of myelitis and only one patient had acute encephalitis. Children showed a different course of the disease. Six percent of the patients suffered a chronic course with a disease duration between 6 mths and 6 yrs either as chronic lymphocytic meningitis (1.6%) or as third stage chronic encephalomyelitis (4.3%). Meningeal signs were rare despite pronounced inflammatory cerebrospinal fluid (CSF) changes (median cell count 160/microliters; median protein concentration 1.13 g/l). High dose i.v. penicillin G was administered to 91% of the patients. Based on the clinical outcome and normalization of CSF no treatment failures were recognized. The final morbidity after a median follow-up of 33 mths was low; disabling sequelae were reported in nine patients, mainly those with previous CNS involvement. We conclude that neuroborreliosis is a common and characteristic neurological disorder. The diagnosis should be based on the demonstration of inflammatory CSF changes and B. burgdorferi specific intrathecal antibody production.


PMID: 1606475

Other references

Melero, J.; Berenguer, M., 2010: Antiviral therapy in patients with HCV-cirrhosis. The main cause of liver cirrhosis and liver cancer in the western world is Hepatitis C virus (HCV) infection. Liver transplantation is the only effective treatment once the disease is decompensated. In viremic patients who undergo transplantation,...

Koss, L.G.; Melamed, M.R.; Daniel, W.W., 1961: In situ epidermoid carcinoma of the cervix and vagina following radiotherapy for cervical cancer. Attention is directed to in situ carcinoma of the cervicovaginal epithelium sequential to radiation therapy for cervical cancer. This is documented in 7 case reports, with time intervals ranging from 1 1/4 to 17 years between the initial therapy a...

Rotgans, J., 1983: "Foetor ex ore" - causes and cure. 1. Der Zahnarzt; Colloquium Med. Dent 27(3): 173-178

Hofmann, K.T.; Consiglio, L., 1971: Dissecting aneurysm of the aorta in a 14-year-old boy. Thoraxchirurgie, Vaskulare Chirurgie 19(1): 76-80

Machado-de-Sousa, Jão.Paulo.; Osório, Fá; Jackowski, A.P.; Bressan, R.A.; Chagas, M.H.N.; Torro-Alves, N.; Depaula, Aé.L.D.; Crippa, Jé.A.S.; Hallak, J.E.C., 2014: Increased amygdalar and hippocampal volumes in young adults with social anxiety. Functional neuroimaging studies have consistently shown abnormal limbic activation patterns in socially anxious individuals, but structural data on the amygdala and hippocampus of these patients are scarce. This study explored the existence of str...

Fazio, S.; Linton, M.F., 2002: Debate: "How low should LDL cholesterol be lowered?" Viewpoint: "It doesn't need to be very low". The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials have shown that the benefits of LDL lowering extend throughout the range of risk...

Arnott, S.R.; Binns, M.A.; Grady, C.L.; Alain, C., 2004: Assessing the auditory dual-pathway model in humans. Evidence from anatomical and neurophysiological studies in nonhuman primates suggests a dual-pathway model of auditory processing wherein sound identity and sound location information are segregated along ventral and dorsal streams, respectively....

Ludwig, W., 1994: Impatiens capensis Meerb in Hesse A first record. Hessische Floristische Briefe 43(1): 14-16

Puder M.; Weidenfeld J.; Chowers I.; Nir I.; Conforti N.; Siegel R.A., 1982: Corticotropin and cortico sterone secretion following delta 1 tetra hydro cannabinol in intact and in hypothalamic de afferented male rats. Adult male rats, intact (N) or bearing complete hypothalamic deafferentations (CHD), were injected with .DELTA.1-tetrahydrocannabinol (THC: 5 mg/kg body wt, i.p.) After 45 min, they were decapitated and trunk blood was collected for serum ACTH and...

Yajima, N.; Kurata, Y.; Sawai, T.; Takeshita, Y., 1993: Comparative studies in induction of micronuclei by three genetically recombinant and urinary human erythropoietins. Comparative studies on the induction of micronucleated erythrocytes by three recombinant human erythropoietins (rhEPOs) such as epoetin alpha, epoetin beta, and SNB-5001, and by urinary human EPO (uhEPO) were carried out in vivo. Small but signifi...