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The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1

, : The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. Journal of Experimental Medicine 174(6): 1461-1466

A skin-associated population of memory T lymphocytes, defined by expression of the cutaneous lymphocyte antigen (CLA), binds selectively and avidly to the vascular lectin endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation. Here we present evidence that CLA itself is the (or a) lymphocyte homing receptor for ELAM-1. Antigen isolated with anti-CLA monoclonal antibody HECA-452 from human tonsillar lysates avidly binds ELAM-1 transfected mouse cells. Anti-CLA antibody blocks T lymphocyte binding to ELAM-1 transfectants. HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function. The dominant form of CLA on T cells is immunologically distinct from the major neutrophil ELAM-1 ligand, the sialyl Lewis x (sLex) antigen (NeuAc alpha 2-3Gal beta 1-4[Fuc alpha 1-3]GlcNAc), which is absent, weakly expressed, or masked on T cells. However, neuraminidase treatment of CLA+ T cells, but not of CLA- T cells, reveals Lewis x (CD15) structures. In combination with the known requirement for terminal NeuAc alpha 2-3Gal and fucose residues attached to N-acetylglucosamine for ELAM-1 and HECA-452 binding, this finding suggests that CLA may comprise an additionally sialylated or otherwise modified form of sLex. The identification of a lymphocyte homing receptor for skin may permit novel approaches to the diagnosis and therapy of cutaneous and inflammatory disorders.


PMID: 1720810

Other references

Vol'kenshtein, M.V.; Golovanov, I.B.; Tsygankova, I.G., 1992: Simulation of biopolymers structure. A simple approach for simulation of structure of biopolymers and their complexes is developed, including methods for conformational analysis mchlt in vacuum mchgt and methods for estimation of free energy of transfer between organic phase and wate...

Paris, D.B.B.P.; Trounson, A.O.; Paris, M.C.J., 2002: In vitro cell culture from the Black Rhinoceros A novel approach to genetic conservation. Theriogenology 57(1): 587, January 2

Bonica J.J., 1979: Importance of the problem. Bonica, J J And V Ventafridda (Ed ) Advances in Pain Research And Therapy, Vol 2 International Symposium on Pain Of Advanced Cancer, Venice, Italy, May 24-27, 1978 Xxix+702p Raven Press: New York, N Y , Usa Illus P1-12

Freeman, L.J.; Ferguson, N.; Fellenstein, C.; Johnson, R.; Constable, P.D., 2017: Evaluation of learning curves for ovariohysterectomy of dogs and cats and castration of dogs. OBJECTIVE To define learning curves for fourth-year veterinary students performing ovariohysterectomy procedures in dogs and cats and castration in dogs. DESIGN Retrospective study. SAMPLE 3,196 ovariohysterectomies or castrations performed in dog...

Oh, R.; Tamaoki, B., 1971: Occurrence of 19-oxoandrost-4-ene-3,17-dione in the course of oestrogen biosynthesis by equine testicular microsomes. Acta Endocrinologica 67(4): 665-676

Vegni, L.; Andrei, A., 1960: Feeding by tube in surgical disease: use of a special tube with 2 lumina. Atti Della Accademia Dei Fisiocritici in Siena. Sezione Medico-Fisica 7: 72-82

Campbell, D.J.; Sage, R.H., 1977: Eosinophilic granuloma. Journal of the Royal College of Surgeons of Edinburgh 22(2): 150-153

Xiao, L.; Herd, R.P.; Majewski, G.A., 1994: Comparative efficacy of moxidectin and ivermectin against hypobiotic and encysted cyathostomes and other equine parasites. Efficacies of moxidectin and ivermectin were compared in four groups of eight ponies with natural parasite infections: placebo (Control), oral moxidectin gel at 0.3 mg kg-1 of body weight (Mox 0.3), oral moxidectin get at 0.4 mg kg-1 of body weigh...

Zhuang, P.; Wo, D.; Xu, Z-Guang.; Wei, W.; Mao, H-ming., 2016: Dynamic changes in plasma tissue plasminogen activator, plasminogen activator inhibitor-1 and beta-thromboglobulin content in ischemic stroke. The aim of this paper is to investigate the corresponding variations of plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities, and beta-thromboglobulin (β-TG) content in patients during different stag...

Zurek, L.; Schal, C.; Watson, D.W., 2000: Diversity and contribution of the intestinal bacterial community to the development of Musca domestica (Diptera: Muscidae) larvae. The bacterial diversity in the intestinal tract of Musca domestica L. was examined in larvae collected from turkey bedding and corn silage. Aerobic culturing yielded 25 bacterial species, including 11 from larvae collected from turkey bedding and...