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The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine


, : The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine. Australian Journal of Experimental Biology and Medical Science 63: 9-18

P. falciparum malaria was cultured in vitro in the presence of sera from patients with cerebral malaria, meningitis and also after chloroquine administration. Intra-erythrocytic parasite damage was seen by light and electron microscopy. The significance of the results is discussed with relevance to non-specific immune mechanisms, and the damage induced by these mechanisms compared with that from chloroquine.

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PMID: 3893406


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