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The effect of endothelial cell proliferation in vitro


, : The effect of endothelial cell proliferation in vitro. Experimental Pathology 31(2): 89-94

The proliferation of bovine aortic endothelial cells is highly stimulated by using a plasma clot instead of glass or plastic as a substrate. The cells form a dense monolayer which is usually under grown by a second layer of endothelial cells showing a more reticular growth pattern. When endothelial cells attached to a plasma clot are covered with a second layer of coagulated plasma, the cells arrange to shapes which bear a great resemblance to capillary structures. It seems that this endothelial cell property is only expressed when the entire cell surface is forced to interact with a surrounding adhesive matrix.

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PMID: 3609236


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