+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of theophylline and immobilization stress on haloperidol-induced catalepsy and on metabolism in the striatum and hippocampus, studied with lactography

, : The effect of theophylline and immobilization stress on haloperidol-induced catalepsy and on metabolism in the striatum and hippocampus, studied with lactography. Neuropharmacology 30(5): 469-473

Whether inducing catalepsy in the rat by an intraperitoneal injection of haloperidol (0.5 mg/kg) had an effect on metabolism in the striatum and in the hippocampus, as determined by lactography, and whether reducing the cataleptic state with stress or theophylline (8 mg/kg i.v.) had any impact on metabolism in these two regions of the brain was investigated. Furthermore, whether theophylline reduced catalepsy in rats through the adrenals was investigated. Haloperidol caused a significant increase in the metabolism of lactate, both in the striatum and in the hippocampus. Reducing haloperidol-induced catalepsy with short-term immobilisation stress did not affect the metabolism of lactate, neither in the striatum nor in the hippocampus. Reducing haloperidol-induced catalepsy with theophylline caused a significant rise in the metabolism of lactate in the striatum, while no effect was seen in the hippocampus. Adrenalectomy did not compromise the anti-cataleptic property of theophylline. It is concluded theophylline is a potent antagonist of haloperidol-induced catalepsy, and that this effect is not mediated by the adrenals. Furthermore, it is reported that haloperidol influenced metabolism in regions of the brain not considered to be its primary target. Lactography is considered to be a very useful tool in the study of metabolism during activity.


PMID: 1865993

Other references

Chesalin, G.A., 1962: The effectiveness of herbicidal application in cereals, legumes and other agricultural crops.. Some recent work with herbicides in field crops in the USSR is surveyed. The rates of 2, 4-D and MCPA recommended for controlling broad-leaved weeds in cereal crops in the USSR are listed. For Avena fatua, barban (as Carbyne) at 0.74 kg/ha gave ex...

Bozic, N.; Vujcic, Z.; Mrdakovic, M.; Ivanovic, J.; Nenadovic, V., 2001: Midgut proteinase activities of Cerambyx cerdo (Coleoptera, Cerambycidae) larvae fed on different diets. Total proteolytic and leucyl aminopeptidase activities were analysed in the midgut of C. cerdo larvae from the environment collected in December; larvae fed on modified artificial diet; and larvae fed on the same artificial diet but with royal jel...

Kruszka, P.S.; Kirmse, B.; Zand, D.J.; Cusmano-Ozog, K.; Spector, E.; Van Hove, J.L.; Chapman, K.A., 2014: Concurrent non-ketotic hyperglycinemia and propionic acidemia in an eight year old boy. NlmCategory="UNASSIGNED">This is the first reported case of a patient with both non-ketotic hyperglycinemia and propionic acidemia. At 2 years of age, the patient was diagnosed with non-ketotic hyperglycinemia by elevated glycine lev...

Veron, M.H.; Couble, M.L.; Caillot, G.; Hartmann, D.J.; Magloire, H., 1990: Expression of fibronectin and type I collagen by human dental pulp cells and gingiva fibroblasts grown on fibronectin substrate. Specific antibodies and indirect immunoperoxidase labelling were used to study the intracellular production of collagen and fibronectin by cells grown on fibronectin-coated glass; the same cell populations seeded on uncoated glass were used as con...

Schwagele, F., 2007: The carry-over of DNA-fragments from maize into tissue of poultry and mammals: investigations on from normal and gentechnically modified maize. The main part of the worldwide-produced genetically modified plants (GMP) is used for animal nutrition. The question arises if there is a transfer of fragments of transformed DNA from the GMP via intestine and blood into the tissue of animals. For...

Daniel Riesco, C.; Garagarza, J.M.; Ortíz Melón, F.; Domenech Delgado, J.; Prieto Solís, J.A., 1977: Long-term follow-up of patients with disorders of intraventricular conduction in the acute phase of myocardial infarct. Revista Espanola de Cardiologia 30(5): 493-501

Strelkoff, T.; Clemmens, A., 1994: Dimensional analysis in surface irrigation. The surface-irrigation design process requires multiple analyses of surface irrigations to test tentative values of design parameters in the search for an optimum. Preparation of general design charts can aid the design process if the users'...

Brown, R.C.; Kelleher, J.; Walker, B.E.; Losowsky, M.S., 1979: The effect of wheat bran and pectin on paracetamol absorption in the rat. 1. The absorption of an oral dose of paracetamol was measured in rats given either a basal fibre-free diet, or the basal diet with either pectin or bran added. 2. Urinary excretion of the oral dose was significantly greater during the first 8 h in...

Kallweit, E.H.nning, M., 1984: Why apparative classification? Marketing of swine-halves after slaughtering. Tierzuchter 36(5): 207-209

Brolemann, H.W., 1896: Myriapodes recueillis en Indo-Chine et offerts au Museum par M. Pavie. Note preliminaire. Bulletin du Museum Paris, 332 & 333