+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The efficacy of orally administered theophylline, inhaled salbutamol, and a combination of the two as chronic therapy in the management of chronic bronchitis with reversible air-flow obstruction

, : The efficacy of orally administered theophylline, inhaled salbutamol, and a combination of the two as chronic therapy in the management of chronic bronchitis with reversible air-flow obstruction. American Review of Respiratory Disease 131(5): 747-751

The efficacy of bronchodilator therapy was assessed in the long-term management of patients with chronic bronchitis and varying degrees of reversible air-flow obstruction. Twenty-five patients with a mean forced expiratory volume in one second (FEV1) 38.7% predicted received: optimized doses of orally administered, sustained-release theophylline, inhaled salbutamol (200 micrograms 4 times a day), a combination of the 2 drugs, and identical placebo therapy for periods of 3 wk in a randomized, double-blind, crossover trial. Patients who deteriorated during treatment were assessed immediately and designated "treatment failures" if additional therapy proved necessary. Such "failures" occurred in 9 patients with placebo, in 8 with salbutamol, in 6 with theophylline, and in only 1 with combined therapy. Using a ranking system based on "treatment failures" and mean daily peak flow rates, first preference was given to combined therapy in 13 patients, theophylline in 6, salbutamol in 4, and placebo in 2. Thus, both combined therapy (p less than 0.001) and theophylline (p less than 0.05) were better than placebo, but this was not so for inhaled salbutamol. Objective improvements in FEV1 and forced vital capacity were a consistent finding with combined therapy compared with placebo, although not with single agents, and additive effects were clearly demonstrated. In the subgroup of patients able to tolerate placebo therapy, no subjective benefit could be discerned during any of the 3 periods of active treatment. Thus, the combination of orally administered, sustained-release theophylline and inhaled salbutamol offered significant advantages in the clinical control of patients with chronic bronchitis with air-flow obstruction.


PMID: 4003919

DOI: 10.1164/arrd.1985.131.5.747

Other references

Baouz, S.; Woisard, A.; Sinapah, S.;, J-Pierre.; Argentini, M.; Bulygin, K.; Aguié, G.; Hountondji, C., 2010: The human large subunit ribosomal protein L36A-like contacts the CCA end of P-site bound tRNA. Periodate-oxidized tRNA (tRNAox), the 2',3'-dialdehyde derivative of tRNA, was used as a zero-length active site-directed affinity labeling reagent, to covalently label proteins at the binding site for the 3'-end of tRNA on human 80...

Rapoff, A.J.; Markel, M.D.; Vanderby, R., 1995: Mechanical evaluation of transosseous wire rope configurations in a large animal external fixator. By use of wire ropes as the transosseous component, an external skeletal fixator for the repair of long bone fractures in horses and cattle has been designed and tested in axial compression. Theoretical methods were used in the design process to s...

Hirasawa T.; Hashimoto M., 1975: Fine structure of human placenta at the early stage of pregnancy with special reference to origin and fine structure of the placental fibrinoid. Japanese Journal of Clinical Electron Microscopy 8(5/6): 433-434

Araneda, S.; Mermet, N.; Verjat, T.; Angulo, J.F.ancisco; Radicella, J.P.blo, 2001: Expression of Kin17 and 8-OxoG DNA glycosylase in cells of rodent and quail central nervous system. Kin17 and 8-Oxoguanine DNA glycosylase (Ogg1) are proteins, respectively, involved in illegitimate recombination and DNA repair in eukaryotic cells. To characterize the expression of these proteins in cell types of rodent and avian brains, we comb...

Vidal, H., 2005: Donnees nouvelles sur les recepteurs PPAR. The nuclear receptors PPAR (Peroxisome Proliferator-Activated Receptors) are transcription factors which form with the retinoid receptor RXR, a PPAR/RXR heterodimer, the functional transcription factor within cells. PPAR receptors are activated by...

Uni, S.; Matsubayashi, M.; Ikeda, E.; Suzuki, Y., 2003: Characteristics of a hepatozoonosis in lungs of Japanese black bears (Ursus thibetanus japonicus). In a survey of pathologic agents in the wild animals of central Japan, we found a Hepatozoon sp. in the lungs of Japanese black bears in Fukui, Shiga, and Gifu Prefectures, Japan. Histopathologic examination of organs and tissues from the 18 bears...

Bicocchi R.; Sighinolfi L.; Bedetti A.; Rossi M.R.; Libanore M.; Ghinelli F., 1992: Epidemiological features of hiv related diarrhoea in northeastern italy. Viii International Conference on Aids And The Iii Std World Congress Published Abstracts Submitted to The Viii International Conference on Aids And The Iii Std World Congress; Harvard-Amsterdam Conference, Amsterdam, Netherlands, July 19-24, 220p Viii International Congress And The Iii Std World Congress: Amsterdam, Netherlands Paper : 134

Anonymous, 1973: Asymmetrical hepatic fibrosis in children. British Medical Journal 3(5879): 510-510

Kuznetsova L.S., 1969: The effect of super phosphate production on the course of pregnancy and births. Trudy Moskovskogo Oblastnogo Nauchno-Issledovatel'skogo Instituta Akusherstva i Ginekologii (4): 248-252

Bose, B., 1981: Hemangiopericytoma: a clinicopathologic and ultrastructure study. World Journal of Surgery 5(6): 863-871