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The epidermal pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH inhibits murine hair growth in vivo and in vitro


, : The epidermal pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH inhibits murine hair growth in vivo and in vitro. Dermatologica 183(3): 173-178

Tissue growth may be controlled by negative feedback mechanisms. Recently, a pentapeptide, pyroGlu-Glu-Asp-Ser-GlyOH ('epidermal pentapeptide', EPP), which slows the growth of mouse epidermis in vivo and of mouse keratinocytes in vitro, was isolated from mouse epidermis. Since inhibitory molecules like EPP might be part of the feedback systems underlying hair growth control, we assessed the effect of synthesized EPP on the growth of hair follicles, using rodent in vivo and in vitro assays. We report for the first time that intraperitoneally injected EPP (30 nmol/animal/day over 6 days) significantly slows the growth of hair follicles in plucking-induced anagen skin of C57 B1-6 mice (as assessed by microscopic morphometry). Using an in vitro organ culture assay, EPP inhibits the incorporation of 3H-thymidine into mouse pelage anagen follicles. That this epidermal-derived peptide affects hair growth raises the possibility that hair growth may be regulated by an inhibition/disinhibition mechanism under participation of EPP-like molecules and that the epidermis may play a role in the control of hair growth.

US$29.90

PMID: 1743383


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Geiser, K.; Tickner, J.; Edwards, S.; Rossi, M., 2015: The Architecture of Chemical Alternatives Assessment. Chemical alternatives assessment is a method rapidly developing for use by businesses, governments, and nongovernment organizations seeking to substitute chemicals of concern in production processes and products. Chemical alternatives assessment i...

Tsuji, A.; Oka, S.; Matsushita, R.; Takada, J.; Sakurai, H., 1995: Superoxide anion scavenging activity and metal contents of coffee. ASSOCIATION SCIENTIFIC INTERNATIONALE DU CAFE [Author] 16th International Scientific Colloquium on Coffee Vols 1 and 2 2) 208-217

Kuzin, V.G., 1979: Celiac artery crush syndrome. Vestnik Khirurgii Imeni I. I. Grekova 122(6): 121-122

Barnett, E.M.; Evans, G.D.; Cassell, M.D.; Perlman, S., 1994: Anterograde viral tracing of trigeminal pain pathways from the tooth pulp to cortex using herpes simplex virus. Pediatric Research 35(4 PART 2): 378A

Braith, R.W.; Mills, R.M.; Wilcox, C.S.; Wood, C.E., 1993: Endocrine basis for fluid balance abnormalities in heart transplant patients. Circulation 88(4 PART 2): I262

Hart, M.R.; Walker, H.G.J. ; Graham, R.P.; Hanni, P.J.; Brown, A.H.; Kohler, G.O., 1980: Steam treatment of crop residues for increased ruminant digestibility 1. effects of process parameters. Rice straw, sugar cane bagasse and sugar cane field trash were steam treated at pressures of 7.0-42.2 kg/cm2 with and without added chemicals. Aqueous NaOH, NH3 and urea were additives used at levels of up to 4.5% of dry weight. Effect of processi...

Foissner, Wilhelm., 1992: Evaluating water quality using Protozoa and saprobity indexes. Unknown

Il inskiy G.A.; Krylova L.Y., 1974: Dispersion of refractive index of zircon. Doklady Akademii Nauk SSSR 214(6): 1417-1418

Matterne, U.; Diepgen, T.L.; Weisshaar, E., 2012: A longitudinal application of three health behaviour models in the context of skin protection behaviour in individuals with occupational skin disease. Occupational skin disease (OSD) is common, associated with poor prognosis and poses a significant burden to the individual and society. We applied the theory of planned behaviour (TPB), the prototype-willingness model (PWM) and the health action p...

Blaschke, D., 2002: The sustainable strategy environment, nutrition, health of the German government. The bovine spongiform encephalopathy crisis in Germany in 2001 and its consequences have made it clear to everyone that changes in agricultural policy are imperative, that a new course must be set. The population's confidence in food safety h...