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The pathogenesis of Lyme disease

, : The pathogenesis of Lyme disease. Rheumatic Diseases Clinics of North America 15(4): 711-726

Lyme disease affects several major organ systems and leads to chronic illness. The pathogenesis of this disease appears to be centered around the long-term persistence of the organisms in tissues. In Lyme disease, isolations of B. burgdorferi are rare. It is thought that few organisms actually invade the host and that host mediators amplify the inflammatory response. Immune and nonimmune phagocytosis leading to bacterial killing occurs in Lyme disease. This organism shows preference for cell surfaces and tissues which may explain the paucity of isolations but also displays characteristic nonspecificity in its adherence to eukaryotic cells. This lack of specificity may explain its capacity to reside and injure vastly different tissues. Autoimmune mechanisms may coincide with spirochetal persistence in the pathogenesis of chronic Lyme disease.


PMID: 2555848

Other references

Broadfoot, W.M., 1951: Forest planting sites in North Mississippi and West Tennessee. Soils of the most common sites are described and planting recommendations are given. In deep or shallow soils with the surface 6-in. consisting mostly of topsoil, good results may be expected with hardwoods on moist lower slopes and bottoms, and w...

Demirdöven, N.; Khalil, M.; Golonzka, O.; Tokmakoff, A., 2007: Dispersion compensation with optical materials for compression of intense sub-100-fs mid-infrared pulses. We report on the generation of essentially transform-limited mid-infrared pulses as short as 75 fs centered at 5mum with 6muJ of energy. Infrared materials with group-velocity dispersion values of opposite sign are used in combination to null seco...

Benker, G.; Vosskühler, A.; Hoff, H.G.; Windeck, R.; Reinwein, D.; Klein, E., 1983: Thyroid function after bronchography with propyliodone. Thyroid function was studied in 27 subjects who underwent bronchography with propyliodone (18-70 ml, containing 30% of organic iodine). Sustained elevations of serum non-hormonal iodine were observed, indicating that significant amounts of propyli...

Bagga, P.S.; Wilusz, J., 1999: Northwestern screening of expression libraries. Methods in Molecular Biology 118: 245-256

Wagner M.S.; Bennett L.R.; Gonick H.C.; Kramer H., 1971: Technetium 99m di ethylenetriamine penta acetic acid a comparison with iodine 131 hippuran for gamma camera studies and iodine 125 iothalamate clearances in chronic renal disease. Journal of Nuclear Medicine 12(6): 470

Schrümpf, E., 1966: Therapeutic results with a new ointment foundation on basis of synthetic glycerides of saturated fatty acids. Dermatologische Wochenschrift 152(26): 660-671

Iso, H.; Sato, S.; Kitamura, A.; Naito, Y.; Shimamoto, T.; Komachi, Y., 2003: Fat and protein intakes and risk of intraparenchymal hemorrhage among middle-aged Japanese. The authors examined the relation between low intakes of saturated fat and animal protein and risk of intraparenchymal haemorrhage in a 14-year prospective study (ending in 1997) of 4775 individuals in Japan aged 40-69 years who undertook a single...

Zucker, B.A.; Müller, W., 2002: Air microorganisms in animal housing--4. Airborne gram-negative bacteria and airborne endotoxin in pig houses. The species composition of airborne gram-negative bacteria and the relationship between inhalable endotoxin, inhalable dust and airborne bacteria were studied in 4 pig houses. The airborne gram-negative bacterial flora was dominated by Enterobacte...

Fen, C.H.; Barbosa, E.R.; Miguel, E.C., 2001: Gilles de la Tourette syndrome: a clinical study on 58 cases. Gilles de la Tourette's syndrome (GTS) is a neuropsychiatric disorder with a childhood onset and is characterized by motor and vocal tics. Fifty-eight patients with GTS were evaluated during a period of three years. Thirty-six patients were m...

Sehmel G.A., 1980: Particle resuspension; a review. Published numerical values of resuspension variables, rates, factors, and weathering half-lives are summarized. Results of the review show the great uncertainty in accurately predicting resuspension. Resuspension rates range over six orders of mag...