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The role of macrophages in the anti-tumor resistance of the body in metastasis

, : The role of macrophages in the anti-tumor resistance of the body in metastasis. Eksperimental'naia Onkologiia 11(6): 11-16

Data on the participation of macrophages in the control of tumour growth and metastatic spreading are presented. Information about the macrophage activation and secretion of soluble cytotoxic factors is given. Certain biochemical mechanisms related to the antimetastatic activity of macrophages are presented. A conclusion is drawn on the possibility of macrophages to stimulate the tumour growth in certain cases. This possibility should be taken into account during the antimetastatic therapy with macrophage activators.


PMID: 2684604

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