geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Theoretical considerations for improving tumour targeting


, : Theoretical considerations for improving tumour targeting. British Journal of Cancer. Supplement 10: 70-73

To determine the relative importance of factors influencing tumour uptake of antibodies, we used a mathematical model to simulate intravenous injection of substances of varying molecular sizes and tumour-binding affinities at several dose levels. The FACSIMILE program was used to simulate the time course of tumour uptake of the tumour-binding substance by calculating the instantaneous tumour content (TC) and tumour:background uptake ratios (UR). Relative total doses to tumour and normal tissue were calculated by integration of TC/time curves. The model was used to make theoretical predictions on the effects of altering different parameters. The size of the injected dose in relation to the number of tumour receptors was crucial:if too low, uptake could not be improved by manipulating other variables, and if too high, the UR for large binding molecules was reduced. Using the standard scanning dose of labelled antibody, absolute numbers of labelled molecules binding to tumour could be increased by injection of a large excess of unlabelled molecules. Given an adequate dose, peak tumour content increased with increasing affinity up to receptor saturation. The peak uptake ratio rose progressively with affinity for a small ligand, but reached a relatively low plateau for antibody due to constant high background levels. At low doses such as those currently administered for diagnostic scanning with antibody, no effect of increasing affinity was predicted.

US$29.90

PMID: 2383483


Other references

Sarkar,K., 2008: Special Issue Economics and business of sports. This special issue consists of 7 papers covering various topics in sports economics, including: the determinants of women's international soccer performance; the economic impact of sporting events; sports participation; athlete compensation/s...

Snell, T.B., 1938: Haemolytic Anaemia in a Newborn Infant. Proceedings of the Royal Society of Medicine 32(2): 96-98

Wolfe, G.L., 2005: Preventive maintenance redefined. Biomedical Instrumentation & Technology 39(5): 408-408

Woodruff, A.; Xu, Q.; Anderson, S.A.; Yuste, R., 2009: Depolarizing effect of neocortical chandelier neurons. Chandelier (or axo-axonic) cells are one of the most distinctive types of GABAergic interneurons in the cortex. Although they have traditionally been considered inhibitory neurons, data from rat and human neocortical preparations suggest that chan...

Dev,S.R.S.; Padmini,T.; Adedeji,A.; Gariepy,Y.; Raghavan,G.S.V., 2008: A comparative study on the effect of chemical, microwave, and pulsed electric pretreatments on convective drying and quality of raisins. In order to discourage the use of chemicals in raisin processing, the effect of microwave and pulsed electric field (PEF) pretreatments on the drying rate and other quality parameters like color, total soluble solids, bulk density, appearance, and...

Khrapkova, N.V., 1962: Data on the development and distribution of larvae and fry of the flying halfbeak. An exceedingly large concentration of larval O. micropterus was found in April between the latitudes of 3 and 9[degree]N at a water temperature of 28-29[degree] (23-30[degree]C). In larvae and fry the lower jaw continues to elongate in proportion...

Schoneberger, T., 2005: A Philosopher's War on Poverty of the Stimulus Arguments: A Review of Fiona Cowie's What's Within? Nativism Reconsidered. In What's Within? Nativism Reconsidered 1999 Fiona Cowie addresses three questions: (1) What is nativism? (2) What is meant by calling some trait "innate"? and (3) What types of evidence should be offered when claiming innateness? T...

Laville, C., 1989: Tourism memorandum. The book provides a detailed statistical overview and analysis of tourism in France. Specifically, it covers the place of French tourism in the national, European and world economies; the sector of tourism production, including investment and turn...

Dost, P.; Thürauf, N.; Armbruster, W.; Schoch, B.; Zülke, M.; Fischer, M., 2000: Perforation of the posterior tracheal wall during percutaneous dilatational tracheotomy. Dilatative percutaneous tracheotomy is more and more indicated in intensive-care medicine. We report on the perforation of the posterior tracheal wall observed in 3 patients after this procedure. In 2 patients the tracheo-oesophageal fistula was c...

Elantser, B.V., 1977: In memoriam Professor Boris Vladimirovich Elantsev. Vestnik Otorinolaringologii: 100-100