+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Theoretical prediction of base sequence effects in DNA. Experimental reactivity of Z-DNA and B-Z transition enthalpies

, : Theoretical prediction of base sequence effects in DNA. Experimental reactivity of Z-DNA and B-Z transition enthalpies. Journal of Molecular Biology 207(2): 433-444

Molecular modeling is used to study the sequence dependence of conformation and stability within helically regular duplex Z-DNA. The variations of conformation that are found are sufficiently important to be classified as a new type of polymorphism within the Z family. It is also demonstrated that certain sequences can adopt more than one of these polymorphic forms. Comparison with experimental studies of chemical reactivity within a natural DNA fragment, forced into a left-handed conformation, suggests that the results of our modeling may be used to explain the chemical reactivity observed. Comparison of the Z results with similar studies of the B form allow enthalpies of transition to be calculated as a function of base sequence.


PMID: 2754731

Other references

Gala; Godet; Liauzun; Longere; Maurellet; Pépin; Régis; Vigneron, 1971: Survey on truck drivers. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale 32(3): 326-330

Oonishi, T.; Uyesaka, N., 1995: A possible mechanism of adriamycin transport by P-glycoprotein in mdr1-gene-transfected L5178Y/VMDR/C06 cells Modified hydrophobic vacuum cleaner model. Japanese Journal of Physiology 45(SUPPL 1): S44

Solomon, H.; Kinnucan, H.W., 1991: Effects of export promotion on import demand for U.S. cotton in the Pacific Rim. International trade in agricultural commodities is constrained by government policy interventions at both the macro and micro levels. These interventions regulate the free flow of farm commodities across national borders. Many governments support...

Leon, J.; Barrio, N., 1987: Influence of the phases of the moon in the attraction of trap trees for scolytids of the genus Ips in pine forests of Baracoa. Trap trees were set up in a Pinus plantation in Cuba by felling stems and leaving them with or without the crown, in the shade or in the sun, some being covered with branches. Some of the trap trees were [identified as being] felled during the wax...

Gelade, G.A.; Beurle, R.L., 1973: The influence of subthreshold inducing fields on the detection of discs: an empirical test of the element contribution hypothesis. Vision Research 13(11): 2065-2078

Dunscombe, P.B.; Katz, D.E.; Stacey, A.J., 1984: Some practical aspects of dual-energy CT scanning. British Journal of Radiology 57(673): 82-87

Yamasaki, M.; Sasaki, T.; Tsuzuki, S.; Torii, M., 1984: Stereotyped pattern of lower limb movement during level and grade walking on treadmill. The effects of speed and gradient on stereotyped pattern of temporal-distance parameters of the lower limb in human gait were observed on five male subjects walking on a treadmill. Step length and step duration were consecutively determined by mea...

Gangadharan, C.; Thoh, M.; Manna, S.Kumar., 2010: Late phase activation of nuclear transcription factor kappaB by doxorubicin is mediated by interleukin-8 and induction of apoptosis via FasL. Doxorubicin is one of the most effective molecules used in the treatment of various tumors. Contradictory reports often open windows to understand the doxorubicin-mediated signaling to exert its apoptosis effect. In this report, we provide evidenc...

Mayer, T.; Jagla, B.; Wyler, M.R.; Kelly, P.D.; Aulner, N.; Beard, M.; Barger, G.; Többen, U.; Smith, D.H.; Brandén, L.; Rothman, J.E., 2006: Cell-based assays using primary endothelial cells to study multiple steps in inflammation. Cell-based assays are powerful tools for drug discovery and provide insight into complex signal transduction pathways in higher eukaryotic cells. Information gleaned from assays that monitor a cellular phenotype can be used to elucidate the detail...

Vega, E.; Ruiz, H.; Martínez-Villa, G.; Sosa, G.; González-Avalos, E.; Reyes, E.; García, Jé., 2007: Fine and coarse particulate matter chemical characterization in a heavily industrialized city in central Mexico during Winter 2003. This paper presents the results of the first reported study on fine particulate matter (PM) chemical composition at Salamanca, a highly industrialized urban area of Central Mexico. Samples were collected at six sites within the urban area during F...