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Thermochemotherapy with cisplatin or carboplatin in the BT4 rat glioma in vitro and in vivo


, : Thermochemotherapy with cisplatin or carboplatin in the BT4 rat glioma in vitro and in vivo. International Journal of Radiation Oncology, Biology, Physics 23(1): 109-114

The effect of thermochemotherapy with cisplatin or carboplatin was compared in the BT4-cell line. In vitro: BT4C-cells were treated with different concentrations of cisplatin or carboplatin, with or without simultaneous hyperthermia. In vivo: Inbred BD IX rats with transplanted glioma-like BT4A or glioblastoma-like BT4An tumors on the hind leg were treated with cisplatin (4 mg/kg) or carboplatin (50 mg/kg), with or without local hyperthermia. In vitro the benefit of adding hyperthermia to chemotherapy was similar for cisplatin and carboplatin. For both cisplatin and carboplatin, the difference of treatment effect between thermochemotherapy and chemotherapy alone increased with higher drug concentrations. In vivo hyperthermia clearly enhanced the effect of carboplatin on BT4A tumors. When treating BT4An tumors, thermochemotherapy with cisplatin or carboplatin was equally effective. Both combinations were superior to treatment with hyperthermia alone. Local toxicity and weight loss following thermochemotherapy were comparable when substituting cisplatin with carboplatin.

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PMID: 1572808


Other references

Davenport Peter H.; Nolan W.L., 1990: Geological structure from surface geochemistry. Atlantic Geology 26(2): 193

Lounsky, J., 1961: Bed treatment of roots of witloof chicory for the control of the miners Napomyza lateralis Fall and Ophiomyia pinguis Fall.. Dimethoate applied at 0.3 g. a.i. per sq. m. of bed is recommended for the commercial control of chicory miners . Several other insecticides were also effective and their action is discussed.

Kamaly, N.; Fredman, G.; Subramanian, M.; Gadde, S.; Pesic, A.; Cheung, L.; Fayad, Z.Adel.; Langer, R.; Tabas, I.; Farokhzad, O.Cameron., 2013: Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation and enhance resolution a...

Nagle, D.W.; Anderson, E.G., 1972: Method for establishing electronystagmograms for normal humans subjected to caloric stimulation. Laryngoscope 82(9): 1671-1702

Zhu, A.-Min; Liang, Y.-Quan; Huang, D.-Ming; Hu, X.-Jian; Wu, S.-Gui; Hu, C.-Lin, 2009: Study on starting-feeding size and food selection of larval and juvenile paddlefish polyodon spathula. Acta Hydrobiologica Sinica 33(6): 1202-1206

Anonymous, 2002: Meeting explores gender differences in viral load. On January 29, 2000, Project Inform co-sponsored a meeting with the National Institute of Health's Office of AIDS Research and the National Institute of Child Health and Human Development on the issue of gender differences in HIV levels. The...

Kostakou, K.; Giannakopoulos, G.; Diareme, S.; Tzavara, C.; Doudounakis, S.; Christogiorgos, S.; Bakoula, C.; Kolaitis, G., 2014: Psychosocial distress and functioning of Greek youth with cystic fibrosis: a cross-sectional study. To assess psychosocial functioning and distress of children and adolescents with cystic fibrosis compared to healthy controls. Thirty-six patients with cystic fibrosis aged 8-18 years (24 boys, mean age ± SD: 11.5 ± 2.6 years) and 31 se...

Breton, P.; Arbona, A.; Simon, J.P., 1963: Clinical trial of a sulfonamide diuretic, 4-chlorophenyl-1,3-disulfonamide. Cahiers R. M. F.: Bulletin Medical-Guide du Praticien-Revue Medicale Francaise Suppl 77: 5-11

Erenberg, G., 1972: Drug therapy in minimal brain dysfunction: a commentary. Journal of Pediatrics 81(2): 359-365

Sterndadel, Z.; Peksa, A., 1972: Physiologic methods of contraception. Pielegniarka i Polozna 9: 6-7 Passim