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Ultrastructure and morphometric characteristics of synapses of the cerebral cortex in patients with tumors located in the hypothalamo-hypophyseal system


, : Ultrastructure and morphometric characteristics of synapses of the cerebral cortex in patients with tumors located in the hypothalamo-hypophyseal system. Arkhiv Anatomii, Gistologii i Embriologii 94(1): 25-33

By means of the electron microscopy method using biopsies structure of the cerebral cortex synapses has been investigated in 4 patients with benign tumors, that immediately influence the hypothalamus. The ultrastructure is described and the data on quantitative correlation of unchanged interneuronal contacts and synapses with various manifestation of the structural disturbances are presented. The unchanged synapses make 72%, with an increased amount of the synaptic vesicles-16%, with agglutination of the synaptic vesicles-2%, with destruction of the presynaptic element after the dark type-4%, with other structural changes-6%. Results of the morphometric analysis demonstrate a decreasing functional activity of the interneuronal contacts with some pathological signs.

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PMID: 3365125


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