+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ultraviolet fluorescence of human sera: I. Sources of characteristic differences in the ultraviolet fluorescence spectra of sera from normal and cancer-bearing humans

, : Ultraviolet fluorescence of human sera: I. Sources of characteristic differences in the ultraviolet fluorescence spectra of sera from normal and cancer-bearing humans. Clinical Chemistry 36(11): 1880-1883

The ultraviolet fluorescence emission spectra of sera from apparently healthy persons and of sera from cancer patients frequently show significantly different curve shapes. A biparametric fluorescence method has been developed to use these deviations to detect patients with malignant diseases (Clin Chem 1986;32:1974-8). However, the pathobiochemical reasons for these differences of diagnostic importance have thus far been unclear. To find a relevant explanation for the described effect, we focused our interest on human serum proteins, the materials mainly responsible for the intrinsic fluorescence of sera in this spectral region. Human sera of various protein compositions were selected according to their protein pattern, determined by cellulose acetate electrophoresis, and their intrinsic fluorescence properties were investigated. We found that the emission spectra of human sera were correlated with their relative protein compositions, albumin and alpha-2 globulins being the most significantly correlated with the fluorescence intensity ratios. Because increased percentages of alpha-2 globulins and decreased percentages of albumin frequently accompany malignancies, we suggest that this condition accounts for the differences between the emission spectra of sera from normal and cancer-bearing humans.


PMID: 1700740

Other references

Grof, B.; Courtice, J., 1962: Studies in the growth rates of temperate pastures in a subtropical environment. Bromus catharticus var. Priebe and Phalaris arundinacea, each with Ladino clover, were grown under irrigation and their growth rates and leaf-area indices were measured. The highest total daily increments for B. catharticus/Ladino clover were 85,...

Abrams, P.A., 1987: Alternative models of character displacement and niche shift 2. displacement when there is competition for a single resource. Character displacement or nongenetic niche shift, when competitors become sympatric, can result from changes in the absolute abundance of the resources available, as well as from changes in the relative abundance of different types. A model of com...

Choucair, M.; Ladin, D.; Olson, J.; Han, X.; Saed, G.; Fivenson, D., 1998: Anti-beta1 integrin treatment selectively induces apoptosis in keloid fibroblasts. Journal of Dermatological Science 16(SUPPL 1): S126, March

Strassman, I.B.; Desai, U.R.; Rahman, A.; Hu, L.; Guerin, C., 1997: Intraocular pressure and prostaglandin E2 levels after pars plana vitrectomy in rabbits. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S661

Kaplan, H.Y., 1989: A quick stapler tie-over fixation for skin grafts. A simple method to ensure split-thickness skin graft immobilization is presented. The method uses foam rubber and a staple gun. The method is safe and reliable and saves operating room time.

Mauro, A.; Rigante, D.; Cimaz, R., 2017: Investigational drugs for treatment of juvenile idiopathic arthritis. Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The improvement of knowledge about the pathogenetic mechanisms of JIA and advances in the understanding of pathways linking inflammation and autoimmunit...

Namkoong G., 1986: The populations genetic basis of breeding theory. Gregorius, H -R (Ed ) Lecture Notes in Biomathematics, 60 Population Genetics in Forestry; Meeting Of The International Union Of Forestry Research Organizations, Goettingen, West Germany, Aug 21-24, 1984 Vi+287p Springer-Verlag New York, Inc : Secaucus, N J , Usa; Berlin, West Germany Illus Paper 2-15, 1985

Thoma Klaus; Hornemann Ulrich; Sauer Martin; Schneider Eberhard, 2005: Shock waves; phenomenology, experimental, and numerical simulation. The purpose of this paper is to review the results of long-term cooperation between Dieter Stoffler and the authors in the field of shock wave deformation of minerals and rocks. First, the principal phenomena of shock wave generation and propagati...

Egenti, Lc, 1978: The Danish. Indian forester: 104 (4) 227-237

Deuffic, S.; Costagliola, D., 1999: Is the aids incubation time changing? A back-calculation approach. Contradictory literature was recently published on possible changes in AIDS incubation time over the period 1978-1994. The purpose of this work was to test if a change in incubation time (shortening or lengthening) was observed in France, either g...