+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

omega-6 and omega-3 fatty acids: monolayer packing and effects on bilayer permeability and cholesterol exchange

, : omega-6 and omega-3 fatty acids: monolayer packing and effects on bilayer permeability and cholesterol exchange. Biochemistry International 26(5): 831-841

It has been suggested that the polyunsaturated omega-3 fatty acid, docosahexaenoic acid (DHA), can adopt unique closely packed arrays in lipid bilayers (Glomset and Applegate. (1986) J. Lipid Res. 27, 658-680). These conformations are predicted on the basis of molecular dynamics calculations and are in contrast to the expanded conformations characteristic of omega-6 unsaturated fatty acids. It has also been suggested that close packing of omega-3 acyl chains could have a substantial affect on the physical properties of lipid bilayers (e.g. permeability). We report here some experimental tests of these predictions. Surface pressure-area experiments have been carried out on DHA and its mixtures with stearic and oleic acids. At low surface pressures DHA is more expanded than oleic acid. Extrapolation to the high surface pressures characteristic of lipid bilayers indicates that the area per molecule of DHA is only marginally less than that for oleic acid. Thus there is no compelling evidence to suggest that the average area per molecule of the omega-3 fatty acid is substantially different from the omega-6 fatty acid at high surface pressures. Experiments also show that the permeability of bilayers to glucose and the rates of dissociation of pyrenyl cholesterol from bilayers were similar for bilayers containing DHA compared to bilayers containing oleic acid or linoleic acid.


PMID: 1535197

Other references

O.Flynn J.D., 1969: The management of simple prostatic hyperplasia. British Journal of Hospital Medicine 2(2): 562-564

Saikku, P., 1996: Chlamydia pneumoniae and cardiovascular diseases. Chlamydia infection of the cardiovascular system is associated with pericarditis, endocarditis and myocarditis. Chlamydia particles can also be observed in damaged heart valves. There is now good evidence that the lesions of arteriosclerosis and a...

Alvarez, A.Andrew.A., 2009: The cross-cultural importance of satisfying vital needs. Ethical beliefs may vary across cultures but there are things that must be valued as preconditions to any cultural practice. Physical and mental abilities vital to believing, valuing and practising a culture are such preconditions and it is always...

Madusolumuo, M.A.; Okoye, Z.S.C., 1993: Effect of Sacoglottis gabonensis stem bark extract, a Nigerian palmwine additive, on serum levels of acetaminophen and acetylsalicylic acid. Medical Science Research 21(16): 603-604

Hull E.W.Seabrook, 1971: Toward a Public Policy on the Ocean. Pages 635-666 1971

Young, Carol L., 2000: Tissue stimulation apparatus for wheelchairs and the like. The present invention involves an apparatus for stimulating skin tissue of a nonambulatory individual in a wheelchair or other mobile apparatus. The pouch of the present invention contains a fluid medium which is connected to an agitator which gen...

Flores Foxworth, G.; Coonrod, S.A.; Moreno, J.F.; Byrd, S.R.; Kraemer, D.C.; Westhusin, M., 1995: Interspecific transfer of IVM IVF-derived red sheep embryos to domestic sheep. Two embryo production methodologies were investigated to generate Red sheep embryos for use in an interspecific embryo transfer program. In Experiment 1, 4 multiparous female Red sheep (Ovis orientalis gmelini) were implanted with CIDR type G devi...

Weiser, J., 1965: A new virus infection of mosquito larvae. A virus infection similar to one detected in mosquito larvae by Kellen was observed in larvae of Aedcs annulipes (Mg.) and A. cantans (Mg.) in south-western Bohemia (Czechoslovakia) in 1964 and 1965 . Infection became apparent during the third or...

Chaudhuri, S.K., 1966: Studies of Tylototriton verrucosus (Himalayan newt) found in Darjeeling. Journal of the Bengal Natural History Society, 35: 32-36

Gentleman, D.J., 2010: Biology meets geology through chemistry. Environmental Science & Technology 44(1): 1-2