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15;17 Translocation in acute promyelocytic leukemia

, : 15;17 Translocation in acute promyelocytic leukemia. Cancer Genetics and Cytogenetics 6(4): 331-337

Acute promyelocytic leukemia (APL) is a relatively rare subtype of leukemia that has been reported to be associated with a specific chromosome abnormality, t(15;17). It has been suggested that this translocation may have a geographical distribution and its presence may signify a poorer prognosis. In this present series of 14 patients with APL, 9 patients (64%) had the t(15;17) and 5 did not; however, no significant differences in clinical features or outcome could be found between those who did and those who did not express the translocation. When ethnic backgrounds were explored, no differences were found. More cases of the t(15;17) were found in recent years (7 of 8 patients studied since 1978 compared to 2 of 6 before 1978). This corresponded to changes made in our cytogenetic techniques suggesting that the finding of the t(15;17) may be a function of technique, rather than a real difference in disease entities, and all patients with APL may have the t(15;17) when appropriately studied.


PMID: 6956437

Other references

Zierz, P.; Kiessling, W., 1953: Clinical and experimental studies with azulene-containing ointments and solutions in dermatology. Deutsche Medizinische Wochenschrift 78(35): 1166-1168

Pesini, P.; Detheux, M.; Parmentier, M.; Hokfelt, T., 1998: Distribution of a glucocorticoid-induced orphan receptor (JP05) mRNA in the central nervous system of the mouse. JPO5 (originally referred to as glucocorticoid-induced receptor gene or cDNA clone 4.2) designates a gene originally isolated from murine thymoma WEHI-7TG cells after being treated with glucocorticoids and forskolin. This gene is also induced by d...

Jaros, P.A.; DeLuise, V.P., 1988: Pingueculae and pterygia. Pingueculae and pterygia are benign peribulbar lesions composed of degenerated basophilic subepithelial tissue. Pingueculae do not affect vision, and minor irritation can usually be managed with artificial tears. Pterygia may affect the visual axi...

Arnbom, T.; Fedak, M.A.; Boyd, I.L.; McConnell, B.J., 1993: Variation in weaning mass of pups in relation to maternal mass, postweaning fast duration, and weaned pup behaviour in southern elephant seals Mirounga leonina at South Georgia. Female southern elephant seals, Mirounga leonina, assemble in large groups and each gives birth to a single pup which is nursed for some 3 weeks. Weaning mass is highly variable; some pups are three times as heavy as others at weaning. After weani...

Switak, KH., 1978: Leben in der Wuste Chilomeniscus und Chionactis die Nattern. Aquarium (Bornheim): 12110: 355-359

Lee, Y-Nan.; Chien, C-Ting., 2016: Hearing lessons from flies. Studying the auditory system of the fruit fly can reveal how hearing works in mammals.

Büchel, C.; Wilhelm, C.; Wagner, V.; Mittag, M., 2017: Functional proteomics of light-harvesting complex proteins under varying light-conditions in diatoms. Comparative proteome analysis of subcellular compartments like thylakoid membranes and their associated supercomplexes can deliver important in-vivo information on the molecular basis of physiological functions which go far beyond to that what can...

Cassell G.H.; Lindsey R.J.; Baker H.J.; Hiramoto R.N., 1971: Protective effect of vaccines in experimental mycoplasma pulmonis infection in mice. Bacteriological Proceedings 71: 78

Pessoa, S.B.; Lane, F., 1936: Sobre os Coleopteros do genero Dendropaemon Perty, de S. Paulo e regioes visinhas. Revista de Biologia e Hygiene Sao Paolo, 7: 89-93

Ingram D.L.; Walters D.E.; Legge K.F., 1980: Variations in motor activity and in food and water intake over 24 hour periods in pigs. Groups of weaner pigs and single animals were observed in a temperature-controlled room isolated from external noise and light for periods up to 4 wk. Continuous records were made of motor activity, food intake and water consumption. In the presen...