+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

2,3-Erythro-dihydroxyhexacosanoic acid and homologs: isolation from yeast cerebrin phosphate and determination of their structures

, : 2,3-Erythro-dihydroxyhexacosanoic acid and homologs: isolation from yeast cerebrin phosphate and determination of their structures. Journal of Lipid Research 14(4): 406-414

Homologs of methyl esters of very polar fatty acids were obtained by methanolysis of cerebrin phosphate isolated from baker's yeast. The major ester component was isolated by preparative gas-liquid chromatography and was found to be 2,3-dihydroxyhexacosanoic acid as deduced from the mass spectra of its trimethylsilyl ether and isopropylidene derivative, reaction with periodate, and comparison of its chromatographic behavior with that of synthetic erythro- and threo-dihydroxy acids. Its infrared spectrum supported the above conclusions. From their retention times by gas-liquid chromatography, the homologs were found to be saturated, unbranched 2,3-dihydroxy fatty acids with 24-27 carbon atoms. The synthesis of the new fatty acids, erythro- and threo-2,3-dihydroxyhexacosanoic acids, is also reported. A method for separating trans-2-hexacosenoic acid, a key intermediate of the above synthesis, and its isomer, trans-3-hexacosenoic acid, both formed by dehydrobromination of 2-bromohexacosanoic acid, is also described.


PMID: 4351782

Other references

Graham, R.G.; DePorter, J.G., 1991: Managing nursing quality. Topics in Health Care Financing 18(2): 46-52

Grosshans, E.; Bressieux, A., 1988: Seborrheic eczema (pityriasporosis). Annales de Dermatologie et de Venereologie 115(1): 79-86

Goodman M.; Birk D.E.; Romero Herrera A.E.; Lande M.A.; Dene H.; Barnhart M.I., 1980: Collagen preservation in soft tissue from the magadan siberia ussr mammoth mammuthus primigenius. Febs Letters 114(1): 30-34

Sørup, S.; Benn, C.S.; Poulsen, A.; Krause, T.G.; Aaby, P.; Ravn, H., 2016: Simultaneous vaccination with MMR and DTaP-IPV-Hib and rate of hospital admissions with any infections: A nationwide register based cohort study. In Denmark, live measles, mumps, and rubella vaccine (MMR) is associated with a reduced risk of infectious disease admissions, particularly for lower respiratory tract infections. In low-income countries, simultaneous vaccination (i.e. vaccination...

Ukita, T.; Mizuno, D.; Kosaka, S., 1953: On the vitamin-like activity of 3-carbamyl-pyridinium-halides. Japanese Journal of Medical Science & Biology 6(2): 171-177

Martindale, W.E.; Pittman, J.A.; Wingo, W.J., 1961: Glycogen content of thyroid tissues. Jour Alabama Acad Sci 32(4): 246

Dodd, A.L.; Mansell, W.; Sadhnani, V.; Morrison, A.P.; Tai, S., 2010: Principal components analysis of the hypomanic attitudes and positive predictions inventory and associations with measures of personality, cognitive style and analogue symptoms in a student sample. An integrative cognitive model proposed that ascribing extreme personal appraisals to changes in internal state is key to the development of the symptoms of bipolar disorder. The Hypomanic Attitudes and Positive Predictions Inventory (HAPPI) was d...

Faqi, A.S.; Prohaska, D.; Lopez, R.; McIntyre, G., 2014: Developmental toxicity of the HMG-CoA reductase inhibitor (PPD10558) in rats and rabbits. PPD10558 is an orally active, lipid-lowering 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) being developed as a treatment for hypercholesterolemia in patients who have not been able to tolerate statins because of sta...

Morelli, S.; Vicari, M.R.; Bertollo, L.A.C., 2007: Evolutionary cytogenetics of the Hoplias lacerdae, Miranda Ribeiro, 1908 group A particular pathway concerning the other Erythrinidae fish. The taxonomy/systematics of the Erythrinidae fish is still imprecise, with several doubts on their relationships. Karyotypes and chromosomal characteristics of some species of the Hoplias lacerdae group (Erythrinidae), from different Brazilian hyd...

Vasconcellos, J.D.C.E, 1960: The origin, expansion and adaptation of the species of wheat cultivated in Portugal. A brief survey is given of the evolutionary history of Triticum with specia reference to the principal species and varieties grown in Portugal.