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2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs


, : 2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs. Journal of Medicinal Chemistry 16(3): 191-194


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Hielm-Björkman, A.K.; Kapatkin, A.S.; Rita, H.J., 2011: Reliability and validity of a visual analogue scale used by owners to measure chronic pain attributable to osteoarthritis in their dogs. To assess validity and reliability for a visual analogue scale (VAS) used by owners to measure chronic pain in their osteoarthritic dogs. 68, 61, and 34 owners who completed a questionnaire. Owners answered questionnaires at 5 time points. Criteri...

Davous, P., 1985: Blink rates in Huntington's disease. Neurology 35(3): 449-449

Poe, C.F.; Suchy, J.F.; Witt, N.F., 1936: Toxicity of strychnine for male and female rats at different ages. The toxicity was tested with 4 strychnine salts[long dash]the sulfate, the ben-zoate, the salicylate, and the ortho-nitrobenzoate. White rats of different ages were used. The toxicity was greater for the [female] than the [male] rat and in both ca...

Gjerde, G.E., 1980: Retrograde pressurization of a medical oxygen pipeline system: safety backup or hazard?. Pipeline systems are used in most hospitals today to deliver medical oxygen to patient care areas. Intermittent reports have appeared concerning serious problems and failure with these systems. Mandated reserve systems have not provided the necess...

Ferrada, S.; Hernandez, K.; Montoya, R.; Galleguillos, R., 2002: Estudio poblacional del recurso anchoveta (Engraulis ringens Jenyns 1842) (Clupeiformes, Engraulidae), mediante analisis de ADN. The genetic variability of two nuclear genes, the 4/5 intron of the Calmodulin (CaM) and the ITS (Internal Transcribed Spacers) of the DNAr were studied. The methodology applied in 139 anchovies (E. ringens) from Iquique and Talcahuano, were the P...

Firth W.J.IIi; Messa A.; Reid R.; Wang R.C.; Watkins C.L.; Yielding L.W., 1984: Identification of an acridine photoaffinity probe for trypanocidal action. Acridine derivatives (24) were screened for trypanocidal activity in Trypanosoma brucei to determine which structural features of the acridine molecule confer maximal antiparasitic activity. Syntheses of several new azidoacridine derivatives are r...

Gonzalez, G.; Sourd, D., 1982: Pruning trial with five guava (Psidium guajava) cultivars. Six-year-old guava trees, cultivars E.E.A. 18-40, Belic L-207, N-6, E.E.A. 1-23 and Belic L-97, planted at 8 x 4 m, were pruned to 1.8 m height and 3.0 m crown diameter. Pruning lowered yields in all cultivars except E.E.A. 18-40 in which yields w...

Dolidze E.I.; Gorgadze I.V.; Suladze T.D., 1972: Role of lymphocytes in nucleic acid metabolism in hungry and fed dogs. Soobshcheniya Akademii Nauk Gruzinskoi SSR 67(2): 485-488

Shah, N.R.; Seger, A.C.; Seger, D.L.; Fiskio, J.M.; Kuperman, G.J.; Blumenfeld, B.; Recklet, E.G.; Bates, D.W.; Gandhi, T.K., 2006: Improving override rates for computerized prescribing alerts in ambulatory care. Computerized drug prescribing alerts can improve patient safety, but are often overridden because of poor specificity and alert overload. We developed a selective knowledge base of only clinically significant drug alerts and designated only critic...