+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A cell surface antigen expressed by astrocytes and their precursors

, : A cell surface antigen expressed by astrocytes and their precursors. Glia 8(1): 20-32

Increasing evidence suggests that astrocytes of the mammalian CNS are a heterogeneous population of cells that express a number of common characteristics. In most cases, astrocytes or their precursors contain a class of intermediate filaments, composed in large part of glial fibrillary acidic protein (GFAP). While the expression of GFAP immunoreactivity is a specific characteristic of astrocytes in the vertebrate CNS, not all astrocytes contain detectable levels of glial filaments, particularly during early development. We have isolated a monoclonal antibody termed 7B11 which binds to the surface of astrocytes and glial precursors, but not to other major types of neural cells. The 7B11 antigen is expressed by astrocytes in the adult CNS in vivo and in cultures of developing CNS tissue, but not on cells of the peripheral nervous system. During early development, 7B11 immunoreactivity appears prior to the expression of GFAP and is retained as punctate staining on the surface of most classes of astrocytes. During CNS maturation, however, 7B11 immunoreactivity is lost from the surface of Bergmann glia in the cerebellum, suggesting that differentiative events lead to functionally and antigenically distinct classes of CNS glial cells. In the adult spinal cord, biochemical analysis suggests that the epitope recognized by 7B11 is associated with a group of polypeptides of apparent molecular weights 200-160, 140, and 92 kD. The cellular distribution of 7B11 expression suggests that astrocytes and their precursors share a distinct cell surface antigenic property and that the expression of 7B11 immunoreactivity may be a useful operational marker for astrocytes in the absence of detectable GFAP expression.


PMID: 7685323

DOI: 10.1002/glia.440080104

Other references

Craighead, F.C., 1912: Insects Contributing To The Control Of The Chestnut Blight Disease. Science 36(937): 825-825

Raw, M-Elizabeth., 2017: Mary-Elizabeth Raw. Diagnosed with multiple sclerosis in her 20s, Mary-Elizabeth became severely disabled; she was never confined by her illness and travelled widely. She won 'Mastermind' in 1989, scoring '40 and no passes'.

Wiant, Harry, 1967: Influence of moisture content on soil respiration. The rate of evolution of CO2 from samples of unincorporated organic matter and mineral soil decreased abruptly and ceased at certain moisture contents. These critical moisture values are discussed.

McCann, E.C.; Morrison, R.M.; Miller, B.A., 1967: Panel on pelvic congestion syndrome. Transactions of the New England Obstetrical and Gynecological Society 21: 71-88

Ishida Mizuho; Ooi Masahiro; Fujiwara Hiroyuki, 2003: Real-time operation system for earthquakes (ROSE). Eos, Transactions, American Geophysical Union 84(46, Suppl

Danilov, I.A.; Anichkov, N.M., 2011: Parenchymal-stromal interactions in intestinal gastric cancer. Histological, histochemical, and immunohistochemical investigations were performed in a prognostically favorable intestinal type of gastric carcinoma, by estimating mainly stromal and, to a lesser extent, parenchymal components, as well as their i...

Sanders, G.L.; Rawlins, M.D., 1979: Phenelzine: acetylator status and clinical response. British Journal of Clinical Pharmacology 7(5): 451-452

Ramirez, C.M.; Liu, B.; Aqul, A.; Taylor, A.M.; Repa, J.J.; Turley, S.D.; Dietschy, J.M., 2011: Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations. Lipoprotein cholesterol taken up by cells is processed in the endosomal/lysosomal (E/L) compartment by the sequential action of lysosomal acid lipase (LAL), Niemann-Pick C2 (NPC2), and Niemann-Pick C1 (NPC1). Inactivation of NPC2 in mouse caused s...

Pöpping, D.M.; Wenk, M.; Van Aken, H.K., 2012: Neurologic complications after epidural analgesia. Epidural analgesia is regarded as gold standard after major abdominal or thoracic surgery in combination with general anaesthesia. Apart from well documented positive effects of epidural analgesia on the postoperative period, evidence for the inci...

García, D.A.; Cid-Arregui, A.; Schmitt, M.; Castillo, M.; Briceño, I.; Aristizábal, F.A., 2011: Highly Sensitive Detection and Genotyping of HPV by PCR Multiplex and Luminex Technology in a Cohort of Colombian Women with Abnormal Cytology. Cancer of the uterine cervix (CC) is the second most common cancer in women worldwide. In Colombia, CC is the second most frequent cancer among the entire women population and the first among women aged between 15 and 44 years, with an estimated i...