geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A facile synthesis of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol


, : A facile synthesis of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol. Steroids 35(4): 439-444

A convenient procedure for the synthesis of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol via a modified homologation sequence of the intermediate 3 alpha,7 alpha,12 alpha-triformyloxy-24-oxo-25-diazo-25-homo-5 beta-cholane involving a homogeneous medium is described. This involves treating the intermediate alpha-diazoketone in methanol with a solution of silver benzoate in triethylamine. Grignard reaction of the resulting triformyloxy methyl homocholate yielded 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol. Large amounts of this bile alcohol were needed to further investigate the defect of cholic acid biosynthesis in patients with cerebrotendinous xanthomatosis (CTX).

US$29.90

PMID: 7376230


Other references

Askarova, S.A.; Ioffe, R.Y.; Khakimova, V.K., 1969: On the possibility of using Ni to control wilt in cotton plants. In pot trials, application of 0.05% Ni (as NiSO4) mixed with superphosphate decreased the number of plants infected with Verticillium wilt from 80 in the control pots to 50 and increased seed cotton yields by 11.2%; higher doses produced little or...

Anonymous, 2012: Traitement des volumineuses eventrations abdominales. Les ventrations repr sentent l une des complications classiques de la chirurgie abdominale. Maladie volutive, l ventration va peu peu augmenter de volume avec des cons quences variables sur la paroi abdominale (notion de perte de substance), sur l...

Corsetti Frank A., 1997: Using carbon isotope stratigraphy on basin-scale problems; an example from the Neoproterozoic-Cambrian grand cycles of eastern California. The nature of the carbonate half cycle in the formation of so called "grand cycles" has recently been debated for the Cambrian sections in the White-Inyo/Death Valley region of eastern California. In an attempt to clarify the nature of t...

Prym, R.W.issbach, F.K.ppel, W., 1977: Feed value of whole grain maize. Feldwirtschaft 18 (2) 71-73

Nilsson, S.E.; Tryding, N.; Tufvesson, G., 1968: Serum monoamine oxidase (MAO) in diabetes mellitus and some other internal diseases. Acta Medica Scandinavica 184(1-2): 105-108

Vessella, R.L.; Pantel, K.; Mohla, S., 2007: Tumor cell dormancy: an NCI workshop report. The long latency period that occurs in some patients between initial treatment and evidence of metastases is attributed to tumor cell dormancy. Although the clinical occurrence of these late developing metastases has intrigued the medical communit...

Sánchez-Marroquín, A.; Zermeño, C.; Zamarripa, A.; García, J., 1966: New substrate for the propagation of food yeast on a laboratory scale. Revista Latinoamericana de Microbiologia Y Parasitologia 8(4): 189-195

Wechbanjong, N., 1988: Relationship between mast cells and mouse trigeminal ganglion. Journal of the Dental Association of Thailand 38(1): 1-9

Pauls, M.M.H.; Clarke, N.; Trippier, S.; Betteridge, S.; Howe, F.A.; Khan, U.; Kruuse, C.; Madigan, J.B.; Moynihan, B.; Pereira, A.C.; Rolfe, D.; Rostrup, E.; Haig, C.E.; Barrick, T.R.; Isaacs, J.D.; Hainsworth, A.H., 2017: Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial. Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor th...

Otto, W.; Hempel, W.E.; Goebel, H., 1977: Socio-biorhythm of heart-infarct mortality--the subcycle of weekdays. Examinations of all persons who suddenly on the way died of myocardial infarction who were 70 years old and younger (so-called U-cases) in the GDR from 1970 to 1974 on the basis of certificates of death resulted in a statistically significant diff...