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A long-term study comparing lacidipine and nifedipine SR in hypertensive patients: safety data


, : A long-term study comparing lacidipine and nifedipine SR in hypertensive patients: safety data. Journal of Cardiovascular Pharmacology 23 Suppl 5: S108-S110

The clinical safety of lacidipine, a new dihydropyridine calcium antagonist, has been assessed in a long-term, comparative study in hypertensive patients. Slow-release (SR) nifedipine was used for comparison. The type and incidence of adverse events seen with both drugs are characteristic of the dihydropyridine class of drugs and were mainly due to pharmacologically induced vasodilation, but lacidipine caused a significantly lower incidence of ankle edema than nifedipine SR. There were no unexpected adverse events during the treatment. The addition of atenolol 50 mg once daily did not increase the frequency of adverse events. Therefore, lacidipine can be considered a safe antihypertensive drug, which can be used as a suitable agent for first-line treatment of hypertension.

US$29.90

PMID: 7609496


Other references

Tabernero, J.; Macarulla, T.; Ramos, F.J.; Baselga, J., 2005: Novel targeted therapies in the treatment of gastric and esophageal cancer. Esophageal cancer (EC) and gastric cancer (GC) constitute a major cause of cancer deaths worldwide. Recent improvements in both surgical techniques and adjuvant/neoadjuvant radiotherapy and chemotherapy approaches have increased the survival of pa...

Sardin, J-P., 1990: Le regime alimentaire de la chouette effraie (Tyto alba) en zone humide continentale. Pica, 4-9 No. 12

Kalia, N.R.; Kalia, R.K., 1994: Character association and path coefficient analysis in French bean. Thirty-five determinate and indeterminate genotypes of Phaseolus vulgaris were grown either as a sole crop or intercropped with maize during kharif 1986. Seed yield was positively correlated with biological yield under both cropping systems but ne...

Moretto, M.M.; Khan, I.A., 2016: IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection. Microsporidia, a latent opportunistic infection associated with mild inflammation, is characterized by a strong CD8 T cell response, which has been shown to be CD4 T cell dependent. In this manuscript, we demonstrate that CD4 help is provided via...

Nozaki M.; Morita T.; Matsusiro A.; Iwakura Y., 1985: Inhibition of intermediate filament protein synthesis in t 12 mouse embryos. Development Growth & Differentiation 27(4): 502

Brunini, T.M.C.; da Silva, C.Demézio.; Siqueira, M.A.S.; Moss, M.B.; Santos, Sérgio.F.F.; Mendes-Ribeiro, Aônio.C., 2006: Uremia, atherothrombosis and malnutrition: the role of L-arginine-nitric oxide pathway. The uraemic syndrome is a complex condition that results from an accumulation of multiple waste compounds, combined with failure of the endocrine and homeostatic functions of the kidney in end-stage chronic renal failure (CRF) patients. Recently i...

Horak, E.D.sjardin, D.; Petersen, R., 1990: A new species of Melanotus from the southern Appalachian Mountains. Mycologia 82(4): 493-495

Cattaneo G., 1990: Upper Jurassic-Lower Cretaceous paleogeography of the eastern Rif foreland, Morocco. Reunion Annuelle des Sciences de la Terre 13: 28

Holbert, K.E.; Stewart, B.D.; Eshraghi, P., 1995: Measurement of radioactivity in Arizona groundwater using improved analytical techniques for samples with high dissolved solids. Radiochemical analyses of 667 samples collected over the 5-y period 1989 to 1993 indicate that approximately 2% of Arizona drinking water supplies from groundwater sources violate current regulatory standards. About 1% of the population is affecte...

Liu, Z.; Xin, M.; Qin, J.; Peng, H.; Ni, Z.; Yao, Y.; Sun, Q., 2016: Temporal transcriptome profiling reveals expression partitioning of homeologous genes contributing to heat and drought acclimation in wheat (Triticum aestivum L.). Hexaploid wheat (Triticum aestivum) is a globally important crop. Heat, drought and their combination dramatically reduce wheat yield and quality, but the molecular mechanisms underlying wheat tolerance to extreme environments, especially stress c...