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A mathematical model that applies to protein degradation and post-translational processing of proteins and to analogous processes for other molecules in non-growing and exponentially growing cells

, : A mathematical model that applies to protein degradation and post-translational processing of proteins and to analogous processes for other molecules in non-growing and exponentially growing cells. Journal of Theoretical Biology 108(4): 597-621

A mathematical model is presented that describes first order degradation and post-translational processing of proteins in non-growing and exponentially growing cells. The model applies to proteins that are substrates or products of processing. General equations are presented that can be applied to many different experimental protocols. Application of the model to pulse-chase and continuous labeling experiments is illustrated. The mathematical expressions apply to any cellular component that is synthesized in proportion to cellular mass and is degraded or processed by reactions that follow first order kinetics. However, in this paper, the model is discussed solely as it applies to protein metabolism.


PMID: 6748706

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