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A new method of testing anti-allergic drugs


, : A new method of testing anti-allergic drugs. International Archives of Allergy and Applied Immunology 71(2): 185-187

Rats were sensitized with a single intraperitoneal dose of bovine serum albumin in alhydrogel plus Bordetella pertussis vaccine, and local anaphylaxis was elicited in the paw by soluble antigen 2 weeks later. The response was mainly due to IgE-type antibodies and proved to be highly sensitive to beta-adrenoceptor agonists. Dexamethasone inhibited the response after a lag phase. Methysergide, disodium chromoglycate, diethylcarbamazine, BW 775/c, nordihydroguarjaretic acid, and FPL 55712 were also suppressive, while mepyramine was without effect. A synergism between methysergide and FPL 55712 was shown. Active local paw anaphylaxis appears to be adequate and easily applicable for large-scale screening of anti-allergic drugs.

US$29.90

PMID: 6341256


Other references

Redhead S.A., 1988: Notes on the genus xeromphalina agaricales xerulaceae in canada biogeography nomenclature taxonomy. Eleven of the 13 North American species of Xeromphalina are reported form Canada. A key to 14 North American and northern Eurasian species is given. Type specimens for 9 names were examined. In Canada, subgenus Heimiomyces is represented by two sp...

Zhang, P.; Tian, J.; Rustum, A., 2017: Development and Validation of a Fast Stability-Indicating Ion-Paired Reversed-Phase HPLC Method for the Assay of Thiabendazole and Estimation of Its Related Compounds. Thiabendazole is a benzimidazole-based anthelmintic active pharmaceutical ingredient for the treatment of intestinal pinworm and Strongyloides infections. Thiabendazole is also used as a fungicide to control fungal diseases in fruits and vegetable...

Procaccini, E.M.; Riccio, G.; Casula, L.; Posteraro, G.; Monfrecola, G., 1997: Thirty hours' evaluation of UVB-induced erythema by chromometry and microflowmetry. Background: Individual UVB photosensitivity is usually investigated by determining the minimal erythemal dose (MED). Nevertheless, factors such as room light intensity and subjective experience of the observer can influence the erythema perception...

Dubiel, J.P.; Dubiel, J.S., 1975: Quantitative angiocardiography in the assessment of left ventricular function in mitral valve stenosis. Polskie Archiwum Medycyny Wewnetrznej 53(1): 11-23

Mchugh J.B.D.; Dalager C.R., 1992: Formalin fixation interferes with the detection of aneuploidy in archival specimens obtained from patients with ulcerative colitis. Gastroenterology 102(4 PART 2): A663

Nikolaenko, An, 1979: Criteria of the reclamation condition of soils and underground waters. Gidrotekhnika i melioratsiia: (2) 73-75

Yoshinaga, K.; Morita, K.; Itoh, Y.; Mabuchi, M.; Yamada, S.; Kuge, Y.; Katoh, C.; Ohta, K.; Konno, M.; Kohya, T.; Kitabatake, A.; Tamaki, N., 2000: A new quantitative evaluation of myocardial viability by gated 99mTc Tetrofosmin SPECT during low dose dobutamin infusion. Journal of Nuclear Medicine 41(5 Suppl ): 89P, May

Cope., 1864: Mr. Cope has described a new genus belonging to the Amiurina, which he has named Gronias; it is blin. Mr. Cope has described a new genus belonging to the Amiurina, which he has named Gronias; it is blind, the eyes being rudimentary, covered by the corium; ventral rays eight. G. nigrilabris, sp. n., from Pennsylvania. It is occasionally caught by f...

Y.L.o; J.K.rth; J.E.lis; P.T.C.isp, 1989: Heterogeneous reactions of 1-pristene catalysed by clays under simulated geological conditions. 1-Pristene was chemisorbed by evaporation from pentane solution on kaolinite, illite, bentonite and solvent-extracted Condor oil shale, and maintained at 25–150°C for 0.5–900 h. The reaction products were extracted from the clay with dichloro...

L.P.nnec, G.; Aloui Bejaoui, N.; L.P.nnec, M., 2006: Spermatozoa and phylogenesis of the pectinid bivalve Flexopecten glaber. Gonad of the Mediterranean pectinid Flexopecten glaber was studied in order to describe the morphology 0 and the ultrastructural characteristics of the mature spermatozoa. The spermatozoon has a 2.5[mu]m pyriform head and a 40-45[mu]m flagellum. T...